Cancer patients with chronic pain syndrome: can we improve their quality of life?
https://doi.org/10.17650/1994-4098-2023-19-1-90-98
Abstract
Many patients with different malignancies require analgesic therapy not only at advanced stages of the disease, but also during their diagnosis and treatment, as well as after treatment completion to ensure pain relief. New highly effective painkillers with a lower adverse event burden are critical to improve the quality of life of cancer patients with chronic pain syndrome. Tafalgin (tyrosyl-arginyl-phenylalanyl-glycinamide) is a highly specific μ1-opioid receptor agonist. It is an innovative Russian drug for subcutaneous administration, which has no analogues abroad. This article discusses the results of phase I–III clinical trials assessing tafalgin efficacy, safety, and potential to improve patients’ quality of life.
Keywords
chronic pain syndrome,
cancer,
novel analgesics,
selective μ1-opioid receptor agonist,
Tafalgin,
tetrapeptides
Supporting agencies: The work was performed without external funding
About the Authors
M. M. Konstantinova
Russian Society of Oncomammologists
Russian Federation
Russian Federation
Mariya Mikhaylovna Konstantinova
198255
56 Prospekt Veteranov
Saint Petersburg
R. M. Paltuev
Russian Society of Oncomammologists; N. N. Petrov National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
198255
56 Prospekt Veteranov
197758
68 Leningradskaya St.
Pesochnyy Settlement
Saint Petersburg
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Review
For citations:
Konstantinova M.M., Paltuev R.M. Cancer patients with chronic pain syndrome: can we improve their quality of life? Tumors of female reproductive system. 2023;19(1):90-98. (In Russ.) https://doi.org/10.17650/1994-4098-2023-19-1-90-98
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