A clinical case of preservation of reproductive potential in a patient with invasive cervical cancer

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Abstract

Cervical cancer is a malignant tumor originating from the mucous membrane of the cervix (ectocervix or endocervix). In 2020, 604,000 new cases of the disease were registered, with 342,000 deaths. Today, a significant rejuvenation of this pathology is recorded – the highest incidence rate occurs in the age group from 15 to 39 years.

The cause of the development of cervical cancer is the human papillomavirus of oncogenic genotypes, and in Russia, human papillomavirus types 16 and 18 are found in most patients. Risk factors: early onset of sexual activity, frequent change of sexual partners, refusal of “barrier” type contraceptives, smoking, immunosuppression, the question of the influence of various sexually transmitted infections is being discussed.

The present article describes a clinical case of performing an organ-preserving operation: laparoscopic extended trachelectomy with sentinel lymph nodes determination, urgent cytological and histological studies, with the formation of the obturator apparatus with a soft titanium nickelide implant for invasive cervical cancer in a patient with unrealized reproductive function.

Organ-preserving surgeries in patients with cervical cancer allow preserving childbearing function while maintaining oncological radicality of surgical treatment. A modern, multidisciplinary approach of an oncologist-gynecologist and a reproductologist is the basis of a modern strategy for managing a patient with cervical cancer and unrealized reproductive function.

About the authors

O. V. Korneva

LLC “Center for Family Health and Reproduction “Krasnaya Gorka”

Author for correspondence.
Email: olga.korneva.doc@yandex.ru
ORCID iD: 0009-0005-4712-1525

Olga V. Korneva.

3A Suvorova St., Kemerovo 650044

Russian Federation

A. G. Trishkin

LLC “Center for Family Health and Reproduction “Krasnaya Gorka”; Kemerovo State University

ORCID iD: 0009-0009-6012-7445

3A Suvorova St., Kemerovo 650044; 6 Krasnaya St., Kemerovo 650000

Russian Federation

A. L. Chernyshova

Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences

ORCID iD: 0000-0002-8194-2811

5 Kooperativnyy Pereulok, Tomsk 634009

Russian Federation

K. V. Vyalova

LLC “Center for Family Health and Reproduction “Krasnaya Gorka”

3A Suvorova St., Kemerovo 650044

Russian Federation

References

  1. Sung H., Ferlay J., Siegel R.L. et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021;71:209–49. doi: 10.3322/caac.21660
  2. Stelzle D., Tanaka L.F., Lee K.K. et al. Estimates of the global burden of cervical cancer associated with HIV. Lancet Glob Health 2020. Available at: https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(20)30459-9/fulltext. DOI: S2214109X(20)304599.
  3. World Health Organization. Global strategy to accelerate the elimination of cervical cancer as a public health problem. Available at: https://www.who.int/publications/i/item/9789240014107.
  4. Chernyshova A.L., Kolomiets L.A., Chernov V.I. Radical trachelectomy for cervical cancer. Novosibirsk: SO RAN, 2020. 147 p. (In Russ.)
  5. Novikova E.G., Antipov V.A., Balakhontseva O.S. Radical Abdominal Trachelectomy. Moscow: Prakticheskaya meditsina, 2012. 112 р. (In Russ.)

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