Escalation of adjuvant endocrine therapy for early hormone-dependent HER2-negative breast cancer: to whom, when and why?
https://doi.org/10.17650/1994-4098-2024-20-1-89-103
Abstract
This review presents the evolution of adjuvant endocrine therapy for early hormone-dependent HER2-negative breast cancer, describes late relapse phenomenon, provides clinical rationale for escalation of treatment, analyzes the key stages of the metastatic cascade, and provides a scientific rationale for the introduction of CDK4/6 inhibitors into adjuvant treatment regimens. The main results of two large randomized studies of therapy including abemaciclib (MonarchE) and ribociclib (NATALEE) in patients with early stages of hormone-dependent HER2-negative breast cancer are presented; the oncological results of escalation of treatment and the safety of therapy are assessed.
About the Author
I. V. Kolyadina
Russian Medical Academy of Continuous Professional Education, Ministry of Health of Russia;
V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Russian Federation
Russian Federation
Irina Vladimirovna Kolyadina
2/1 Barrikadnaya St., Moscow 125993, Russia;
4 Akademika Oparina St., Moscow 117198, Russia
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Review
For citations:
Kolyadina I.V. Escalation of adjuvant endocrine therapy for early hormone-dependent HER2-negative breast cancer: to whom, when and why? Tumors of female reproductive system. 2024;20(1):89-103. (In Russ.) https://doi.org/10.17650/1994-4098-2024-20-1-89-103
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