Особенности и сложности лечения BRCA-ассоциированного рака яичника, концепция хронической болезни: обзор литературы

Проанализированы данные литературы об особенностях течения и терапевтических подходах у пациенток с BRCA- ассоциированными карциномами яичника. Консенсусом ESMO-ESGO подчеркнута значимость определения статуса BRCA1/2 при планировании всей лечебной стратегии. BRCA-ассоциированные карциномы существенно отличаются от спорадических форм по характеру клинического течения, особенностям ответа на системную терапию, спектру используемых лекарственных препаратов, механизмам развития химиорезистентности, прогнозу заболевания. Для данной категории пациенток необходимы новые лечебные подходы с разработкой тактики преодоления химиорезистентности и модификацией всей программы комбинированного лечения.

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