Прогестерон и прогестероновые рецепторы при раке молочной железы: прошлое, настоящее, будущее

История изучения прогестерона и прогестероновых рецепторов (ПР) при раке молочной железы сколь легендарна, столь и противоречива. В данном обзоре мы резюмируем раннюю историю изучения  ПР при раке молочной железы, развенчиваем миф о том, что прогестерон вызывает рак, обсуждаем  недавнее открытие того, что ПР регулируют гетерогенность клеток, пытаемся объединить теории,  описывающие ПР как «хорошего» или  «плохого» участника онкогенеза, и обсуждаем новые направления исследований, которые могут помочь  объяснить роль этого загадочного гормона и его  рецепторов. 

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