Embryonic heritage: a unique case of Wolffian duct tumor in a 75-year-old female patient Modern approaches to morphological diagnostics

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Abstract

Female adnexal tumor of Wolffian origin is an extremely rare and poorly studied tumor arising from remnants of Wolffian (mesonephric) duct and having an ambiguous malignancy potential. Immunohistochemical diagnostics of these tumors is important to exclude other pathologies. Interpretation of the prognosis is ambiguous. There are no clear standards for surgical or chemotherapeutic treatment. This is due to the lack of a sufficient number of observations and clinical studies. The article presents a clinical case of Wolffian duct tumor diagnosed in a 75-year-old patient, with a discussion of the terminological, morphological, immunohistochemical and molecular genetic features of the tumor.

About the authors

A. B. Villert

Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences

Author for correspondence.
Email: avillert@yandex.ru
ORCID iD: 0000-0002-2773-1917

Alisa Borisovna Villert

5 Kooperativnyy Pereulok, Tomsk 634009, Russia 

Russian Federation

O. A. Bondyreva

Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences

5 Kooperativnyy Pereulok, Tomsk 634009, Russia

Russian Federation

S. V. Vtorushin

Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences;
Siberian State Medical University, Ministry of Health of Russia

ORCID iD: 0000-0002-1195-4008

5 Kooperativnyy Pereulok, Tomsk 634009, Russia

2 Moskovskiy Trakt, Tomsk 634050, Russia 

Russian Federation

L. A. Kolomiets

Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences;
Siberian State Medical University, Ministry of Health of Russia

ORCID iD: 0000-0002-6854-8940

5 Kooperativnyy Pereulok, Tomsk 634009, Russia

2 Moskovskiy Trakt, Tomsk 634050, Russia 

Russian Federation

M. O. Ochirov

Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences

ORCID iD: 0000-0001-6628-2918

 Россия, 634009 Томск, Кооперативный переулок, 5 

Russian Federation

A. A. Maltseva

Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences

ORCID iD: 0000-0001-8212-731X

5 Kooperativnyy Pereulok, Tomsk 634009, Russia

Russian Federation

S. A. Villert

Siberian State Medical University, Ministry of Health of Russia

 2 Moskovskiy Trakt, Tomsk 634050, Russia 

Russian Federation

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