Lenvatinib in combination with pembrolizumab as first-line therapy for advanced endometrial cancer: clinical case
https://doi.org/10.17650/1994-4098-2025-21-1-142-146
Abstract
The combination of lenvatinib and pembrolizumab has emerged as the first non-chemo treatment for advanced endometrial cancer, particularly in cases refractory to standard therapies. This case describes the efficacy and safety of the combination of lenvatinib and pembrolizumab in the treatment of a 62-year-old patient with endometrioid adenocarcinoma who received first-line therapy with the combination of lenvatinib and pembrolizumab in the absence of repair system deficiency after adjuvant therapy. This combination offers the potential to extend survival in patients with mismatch repair proficient endometrial cancer who have received systemic neoadjuvant or adjuvant therapy.
Supporting agencies: The article was published with the financial support of Eisai Co., Ltd.
About the Authors
E. A. Khachaturyan
Oncology Center No. 1, S. S. Yudin City Clinical Hospital, Moscow Healthcare Department
Russian Federation
Competing Interests:
Russian Federation
Elina Arturovna Khachaturyan
Build. 7, 18A Zagorodnoe Shosse, Moscow 117152
Competing Interests:
The authors declare no conflict of interest
T. G. Antonova
Oncology Center No. 1, S. S. Yudin City Clinical Hospital, Moscow Healthcare Department
Russian Federation
Competing Interests:
Russian Federation
Build. 7, 18A Zagorodnoe Shosse, Moscow 117152
Competing Interests:
The authors declare no conflict of interest
O. A. Stativko
Oncology Center No. 1, S. S. Yudin City Clinical Hospital, Moscow Healthcare Department
Russian Federation
Competing Interests:
Russian Federation
Build. 7, 18A Zagorodnoe Shosse, Moscow 117152
Competing Interests:
The authors declare no conflict of interest
I. A. Pokataev
Oncology Center No. 1, S. S. Yudin City Clinical Hospital, Moscow Healthcare Department
Russian Federation
Competing Interests:
Russian Federation
Build. 7, 18A Zagorodnoe Shosse, Moscow 117152
Competing Interests:
The authors declare no conflict of interest
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For citations:
Khachaturyan E.A., Antonova T.G., Stativko O.A., Pokataev I.A. Lenvatinib in combination with pembrolizumab as first-line therapy for advanced endometrial cancer: clinical case. Tumors of female reproductive system. 2025;21(1):142-146. (In Russ.) https://doi.org/10.17650/1994-4098-2025-21-1-142-146
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