Modern concepts of basic therapy for diffuse dyshormonal dysplasia of the mammary glands
https://doi.org/10.17650/1994-4098-2025-21-2-75-83
Abstract
The presented work is devoted to modern concepts of basic therapy of dyshormonal dysplasia – the most common diffuse disease of the mammary glands. In Russia, one of the most popular medications for the specific correction of mastalgia–mastodynia associated with this disease is Mastodinon. The active component of the drug – the extract of Vitex agnus-castus (chaste tree, monk’s pepper) contains the flavonoid casticin, which determines the therapeutic potential of this plant. The authors present the latest data from the world literature on the clinical and biological effects of сasticin as well as its molecular effects on the processes of epigenetic rearrangements in benign breast dysplasia. Also the potential role of casticin in the prevention of cancer was assessed.
About the Authors
I. V. Vуsotskaya
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation
Competing Interests:
Russian Federation
Build. 2, 8 Trubetskaya St., Moscow 119991
Competing Interests:
The authors declare no conflict of interest
E. A. Kim
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia; N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Competing Interests:
Russian Federation
Build. 2, 8 Trubetskaya St., Moscow 119991
24 Kashirskoe Shosse, Moscow 115522
Competing Interests:
The authors declare no conflict of interest
M. A. Kushnir
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation
Competing Interests:
Russian Federation
Build. 2, 8 Trubetskaya St., Moscow 119991
Competing Interests:
The authors declare no conflict of interest
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For citations:
Vуsotskaya I.V., Kim E.A., Kushnir M.A. Modern concepts of basic therapy for diffuse dyshormonal dysplasia of the mammary glands. Tumors of female reproductive system. 2025;21(2):75-83. (In Russ.) https://doi.org/10.17650/1994-4098-2025-21-2-75-83
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