Benign metastatic leiomyoma: literature review
https://doi.org/10.17650/1994-4098-2025-21-2-115-122
Abstract
The review systematises literature data on pathogenesis, clinical course and treatment of benign metastasising leiomyoma. Benign metastatic leiomyoma is a rare disease, occurring in women of reproductive period, characterised by the presence of multiple benign indolent smooth-muscle mitotically inactive tumours (metastases) of ectopic localisation with a history of uterine leiomyoma and no other tumour process. It is presented in various forms: peritoneal leiomyomatosis, intravenous leiomyomatosis involvement of parenchymal organs, bones, skeletal muscles. Currently, there are no standards for the treatment of patients with benign metastasising leiomyoma. Treatment depends on localisation of metastases and clinical manifestations of the disease: dynamic observation, hormone therapy or surgical treatment.
About the Authors
Kh. B. Kotiv
N. N. Petrov National Medical Research Oncology Center, Ministry of Health of Russia; I. I. Mechnikov North-Western State Medical University, Ministry of Health of Russia
Russian Federation
Competing Interests:
Russian Federation
Khristina Bogdanovna Kotiv
68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758
41 Kirochnaya St., Saint Petersburg 191015
Competing Interests:
The authors declare no conflict of interest
E. M. Khmelevskaia
N. N. Petrov National Medical Research Oncology Center, Ministry of Health of Russia; I. I. Mechnikov North-Western State Medical University, Ministry of Health of Russia
Russian Federation
Competing Interests:
Russian Federation
68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758
41 Kirochnaya St., Saint Petersburg 191015
Competing Interests:
The authors declare no conflict of interest
I. V. Berlev
N. N. Petrov National Medical Research Oncology Center, Ministry of Health of Russia; I. I. Mechnikov North-Western State Medical University, Ministry of Health of Russia
Russian Federation
Competing Interests:
Russian Federation
68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758
41 Kirochnaya St., Saint Petersburg 191015
Competing Interests:
The authors declare no conflict of interest
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For citations:
Kotiv Kh.B., Khmelevskaia E.M., Berlev I.V. Benign metastatic leiomyoma: literature review. Tumors of female reproductive system. 2025;21(2):115-122. (In Russ.) https://doi.org/10.17650/1994-4098-2025-21-2-115-122
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