NON-HODGKIN'S LYMPHOMAS OF FEMALE REPRODUCTIVE SYSTEM
https://doi.org/10.17650/1994-4098-2008-0-1-61-64
Abstract
Non-Hodgkin's lymphomas are extremely rare among all tumors of female reproductive system. Diagnostic mistakes and inadequate therapeu- tic tactics in these diseases are results of usual absence of alertness of gynecologists. The aims are to analyze reasons of diagnostic mistakes in patients with non-Hodgkin's lymphomas of female reproductive system and to discover definitive clinical and morphological characteristics of female reproductive system lymphoid tumors. During the period between 1989 and 2006, 305 cases of primary extranodal non-Hodgkin's lym- phomas were detected; female reproductive system was affected in 7% of patients (totally 40 patients), which were included in investigated group. In the whole analyzed group of women (n=40, median age 43 yrs, range 17-84 yrs), patients with primary lesion of female reproductive system had median age of 40 yrs and with secondary involvement - 46 yrs. Most of patients were fertile (60%, n=24). Such tumors was localized in breast in 40% of cases (n=16), in ovaries - 20% (n=8), in uterine corpus - 12,5% (n=5), in uterine cervix - 15% (n=6), and in vagina - remaining 12,5% (n=5). Average time from diagnosis to beginning of the treatment was 7,5 months. As a result, the onset of specific therapy was delayed in 65% cases (n=26) and 50% (n=20) underwent unneeded surgery. Diagnostic mistakes lead to inadequate treatment. Extranodal non-Hodgkin’s lymphomas of female reproductive system, both primary and secondary, are rare pathology. Primary lesion is more typical for older women, sec- ondary is mainly affecting younger women (in reproductive period). Chemotherapy response and prognosis are better in primary cases.
About the Authors
A. V. Babkina
N.N. Blokhin National Cancer Research Center, Moscow, Russia; Russian Medical Academy of Postgraduate Education, Moscow, Russia
Russian Federation
Russian Federation
B. O. Toloknov
N.N. Blokhin National Cancer Research Center, Moscow, Russia; Russian Medical Academy of Postgraduate Education, Moscow, Russia
Russian Federation
Russian Federation
O. V. Kamaeva
N.N. Blokhin National Cancer Research Center, Moscow, Russia; Russian Medical Academy of Postgraduate Education, Moscow, Russia
Russian Federation
Russian Federation
I. I. Bokin
N.N. Blokhin National Cancer Research Center, Moscow, Russia; Russian Medical Academy of Postgraduate Education, Moscow, Russia
Russian Federation
Russian Federation
A. R. Shafiev
N.N. Blokhin National Cancer Research Center, Moscow, Russia; Russian Medical Academy of Postgraduate Education, Moscow, Russia
Russian Federation
Russian Federation
I. V. Poddubnaya
N.N. Blokhin National Cancer Research Center, Moscow, Russia; Russian Medical Academy of Postgraduate Education, Moscow, Russia
Russian Federation
Russian Federation
References
1. Новак А.А. Эволюция представлений о злокачественных лимфомах и современные взгляды на их классификацию. Мат науч конф «Диагно- стика и лечение злокачественных лимфом». С.-Пб.; 1997. с. 7—17.
2. Hodgkin T. On some morbid appear- ances of the absorbent glands and spleen. Med-Chir Trans (Lond) 1832;17:68—114.
3. Штерн Р.Д. Современное состояние проблемы злокачественных лимфом (к 100-летию учения о злокачественных лимфомах). Арх патол 1984;(12):13—20.
4. Billroth Th. Multiple lymphome. Erfolgreiche Bchandlung mit Arsenik. Wien med Wschr 1871;21(44):1065—8.
5. Волкова М.А. Онкогематология. Неходжкинские лимфомы. М.; 2001. с.236.
6. Greenlee R.T., Murray T., Bolden S., Wingo P.A. Cancer statistics, 2000. CA Cancer J Clin 2000;50(1):7—33.
7. Harris N.L., Jaffe E.S., Stein H. et al. A revised European-American classifica- tion of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 1994;84(5):1361—92.
8. Давыдов М.И., Аксель Е.М. Злокачественные новообразования в России и в странах СНГ в 2005 г. М.; 2004. с. 4—26.
9. Zucca E., Roggero E., Bertoni F., Cavalli F. Primary extranodal non-Hodgkin's lym- phomas. Part 1: Gastrointestinal, cuta- neous and genitourinary lymphomas. Ann Oncol 1997;8(8):727—37.
10. Barzilay J., Rakowsky E., Rahima M., Yanai-Inbar I. Malignant lymphoma of the ovary: report of a case and review of the literature. Obstet Gynecol 1984;64(Suppl 3):93S—4S.
11. Lathrop J.C. Malignant pelvic lym- phomas. Obstet Gynecol 1967;30(1):137—45.
12. Rosenberg S.A., Diamond H.D., Jaslowits B., Craver L.F. Lymphosarcoma: a review of 1269 cases. Medicine 1961;40:31—84.
13. Rotmensch J., Woodruff J.D. Lymphoma of the ovary: report of twenty new cases and update of previous series. Am J Obstet Gynecol 1982;143(8):870—5.
14. Abbas M.A., Birdwell R., Katz D.S. et al. Primary lymphoma of the cervix in a heart transplant patient. Am J Roentgenol 1996;167(5):1136—8.
15. Kuo H.C., Chou C.Y., Chang C.H. et al. Primary malignant lymphoma of the uterine cervix shows favorable response to neoadjuvant chemotherapy. Gynecol Oncol 1994;52(3):408—10.
16. Vang R., Medeiros L.J., Ha C.S., Deavers M. Non-Hodgkin's lymphomas involving the uterus: a clinicopathologic analysis of 26 cases. Mod Pathol 2000;13(1):19—28.
17. Freeman C., Berg J.W., Cutler S.J. Occurrence and prognosis of extranodal lymphomas. Cancer 1972;29(1):252—60.
18. Komaki R., Cox J.D., Hansen R.M. et al. Malignant lymphoma of the uterine cervix. Cancer 1984;54(8):1699—704.
19. Muntz H.G., Ferry J.A., Flynn D. et al. Stage IE primary malignant lymphomas of the uterine cervix. Cancer 1991;68(9):2023—32.
20. Perren T., Farrant M., McCarthy K. et al. Lymphomas of the cervix and upper vagina: a report of five cases and a review of the litera- ture. Gynecol Oncol 1992;44(1):87—95.
21. Bagella M.P., Fadda G., Cherchi P.L. Primary non-Hodgkin lymphoma of the vagina: case report. Clin Exp Obstet Gynecol 1989;16(4):100—2.
22. Castaldo T.W., Ballon S.C., Lagasse L.D., Petrilli E.S. Reticuloendothelial neopla- sia of the female genital tract. Obstet Gynecol 1979;54(2):167—70.
23. Clow W.M., Joannides T., Saleem A.K. et al. An unusual cause of postmenopausal bleeding and incontinence of urine: pri- mary lymphoma of the vagina. Br J Obstet Gynaecol 1995;102(2):164—5.
24. Harris N.L., Scully R.E. Malignant lym- phoma and granulocytic sarcoma of the uterus and vagina. A clinicopathologic analy- sis of 27 cases. Cancer 1984;53(11):2530—45.
25. Волкова М.А. Полвека в терапии хронического лимфолейкоза. Гематол трансфузиол 1998;43(5):6—12.
26. Cohnheim J. Ein Fall von Pseudoleukamie. Arch path Anat Physiol 1865;33:451—4.
27. Reed D.M. On the pathological changes in Hodgkin's desease, with special reference to its relation to tuberculosis. John Hopkins Hosp rep 1902;10:133—96.
28. Sternberg C. Uber eine eigenartige unter dem Bilde der Pseudoleukamie ver- laufende tuberculose des lymphatischen apparates. Heilkundede 1898;19(1):21—90.
29. Virchov R. Die Krankhaften Geschwulste. Dressing Vorlesungen gehalten wahrend das Winterse mesters 1862—1863 an der Univers. Tat 24 Berlin, Bd.-Berlin: Hirschwald; 1865-Bd.2: 1864—1865.
30. Триншпун Л.Д., Воробьев П.А. И.А. Кассирский и время. Воспоминания учеников и друзей. Под ред. А.И. Воробьёва. М., Ньюдиамед-АО; 1998. с. 156.
31. Файнштейн Ф.Э., Зугинидзе И., Полянская А.М., Козинец Г.И. Хронический лифолейкоз. Тбилиси, Сабчота Сакартвело; 1976.
32. Шевченко Ю.А. Военно-медицинская академия — национальные достижения России. Воен мед журн 1998;319(11):5—12.
33. Brill N.E. Generalized giant lymph. Follicle hyperplasia of lymph nodes and splum. A hither to underscribed type. JAMA 1925;84:668—71.
34. Hiddemann W., Longo D.L., Coiffier B. et al. Lymphoma classification - the gap between biology and clinical management is closing. Blood 1996;88(11):4085—9.
35. Поддубная И.В., Дёмина Е.А. Диагностика и определение распространенности (стадирования) неходжкинских лимфом. Практ онкол 2004; 5(3):176—84.
Review
For citations:
Babkina A.V., Toloknov B.O., Kamaeva O.V., Bokin I.I., Shafiev A.R., Poddubnaya I.V. NON-HODGKIN'S LYMPHOMAS OF FEMALE REPRODUCTIVE SYSTEM. Tumors of female reproductive system. 2008;(1):61-64. (In Russ.) https://doi.org/10.17650/1994-4098-2008-0-1-61-64
Views:
441
Email this article 