ALTERNATIVE APPROACHES TO THERAPY FOR ENDOMETRIAL HYPERPLASTIC PROCESSES IN PERIMENOPAUSE

Abstract

The study included 68 perimenopausal patients. Group 1 comprised 34 women with endometrial hyperplastic processes (a study group); Group 2 consisted of 34 women without endometrial pathology (a control group). The authors conducted physical examination, small pelvic ultrasonography, hysteroscopy with endometrial biopsy, measured the urinary estrogen metabolites 2-OHE1/16α-OHE1 ratio by enzyme immunoassay, and determined the levels of total estrogens. Statistically significantly increased 16α-OHE1 concentrations, a low 2-OHE1/16α-OHE1 ratio, and elevated levels of total estrogens were found in Group 1 women. No recurrent endometrial hyper- plasia, as well as lower levels of total estrogens and 16α-OHE1 and a higher 2-OHE1/16α-OHE1 ratio were observed after using indi- nol in a dose of 300 mg/day for 3 months in 20 patients from the study group.