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BREAST CANCER AND IN VITRO FERTILIZATION PROGRAM

https://doi.org/10.17650/1994-4098-2008-0-4-52-56

Abstract

Eleven cases of breast cancer (BC) diagnosed during or after in-vitro fertilization (IVF) are considered. The study group was observed to have cases of familial BC in 18.2% of the patients and BRCA1 gene mutations in 60%. At the same time 45.5% of cases had local- ly advanced and generalized BC, which suggests that there is a tumor at the initiation of a regular IVF cycle. The authors arrive at the conclusion that it is necessary to include a mammologist's examination, breast ultrasonography, and an oncogeneticist's counseling into the package of compulsory measures during IVF.

About the Authors

A. A. Parokonnaya
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Russian Federation


M. I. Nechushkin
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Russian Federation


Ye. B. Kampova-Polevaya
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Russian Federation


L. N. Lyubchenko
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Russian Federation


References

1. Ayhan A., Salman C.A., Celik H. et al. Association between fertility drugs and gynecologic cancers, breast cancer, and childhood cancers. Acta Obstetricia et Gynecologica Scandinavica 2004;83(12). 2. Braga C., Negri E., La Vecchia C. et al. Fertility treatment and risk of breast can- cer. Hum Reprod 1996;11:300—3.

2. Dor J., Lerner-Geva L., Rabinovici J. et al. Cancer incidence in a cohort of infertile women who underwent in vitro fertilization. Fertil Steril 2002;77:324—7. 4. Doyle P., Maconochie N., Beral V. Cancer incidence following treatment for infertility at a clinic in the UK. Hum Reprod 2002;17(8):2209—13.

3. Lerner-Geva L., Keinan-Boker L., Blumstein T. et al. Infertility, ovulation induction treatments and the incidence of breast cancer-a historical prospective cohort of Israeli women. Breast Cancer Res Treat 2006;100(2):201—12.

4. ЛИТЕРАТУРА

5. Ricci E., Parazzini F., Negri1 E. et al. Fertility drugs and the risk of breast can- cer. Hum Reprod 1999;14(6):1653—5.

6. Brzezinski A., Peretz T., Mor-Yosef S. et al. Ovarian stimulation and breast can- cer: Is there a link? Gynecol Oncol 1994;52:292—5.

7. Burkman R., Tang M., Malone K. et al. Infertility drugs and the risk of breast cancer: findings from the National Institute of Child Health and Human development Women's Contraceptive and Reproductive Experiences Study. Fertil Steril 2003;7:844—51.

8. Potashnik G., Lerner-Geva L., Genkin L. et al. Fertility drugs and the risk of breast and ovarian cancers: results of a long-term follow-up study. Fertil Steril 1999;71:853—9.

9. Bernstein L., Hanisch R., Sullivan-Halley J. et al. Treatment with human chorionic gonadotropin and risk

10. of breast cancer. Cancer Epidemiol Biomark Prev 1995;4:437—40.

11. Rossing M.A., Daling J.R., Weiss N.S. et al. Risk of breast cancer in a cohort of infertile women. Gynecol Oncol 1996;60:3—7.

12. Gauthier E., Paoletti X., Clavel-Chapelon F. Breast cancer risk associated with being treated for infertility: results from the French E3N cohort study. Hum Reprod 2004;19(10):2216—21.

13. Brinton L., Scoccia B., Moghissi K. et al. Breast cancer risk associated with ovulation stimulating drugs. Hum Reprod 2004;19(9):2005—13.

14. Pappo I., Lerner-Geva L., Halevy A. The Possible Association between IVF and Breast Cancer Incidence. Ann Surg Oncol 2008;15(4):1048—55.

15. Pappo I. Breast cancer in the elderly: histological, hormonal and surgical char- acteristics. Breast 2007;1:60—7.


Review

For citations:


Parokonnaya A.A., Nechushkin M.I., Kampova-Polevaya Ye.B., Lyubchenko L.N. BREAST CANCER AND IN VITRO FERTILIZATION PROGRAM. Tumors of female reproductive system. 2008;(4):52-56. (In Russ.) https://doi.org/10.17650/1994-4098-2008-0-4-52-56

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ISSN 1994-4098 (Print)
ISSN 1999-8627 (Online)