Место пегилированного липосомального доксорубицина в терапии метастатического рака молочной железы
Аннотация
Обзор посвящен исследованиям пегилированного липосомального доксорубицина (ПЛД) при метастатическом раке молочной железы (мРМЖ), включая монотерапию 1-й линии, «поддерживающую» терапию, комбинации с другими цитостатиками, режимы с трастузумабом при HER-2-позитивном подварианте, а также «терапию спасения» при интенсивно предлеченных формах заболевания. Показано, что ПЛД не уступает обычным антрациклинам по эффективности и значительно превосходит их по безопасности, особенно у больных с высоким риском кардиальных осложнений; отсутствие кумулятивной токсичности и предельно допустимой дозы позволяет проводить терапию до прогрессирования, использовать препарат в качестве «поддержки», а также эффективно и безопасно комбинировать ПЛД с трастузумабом при HER-2-позитивном мРМЖ. Клиническая польза от назначения ПЛД не зависит от чувствительности к обычным антрациклинам. Препарат является также важной опцией лечения таксан-рефрактерного мРМЖ.
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Для цитирования:
Артамонова Е.В. Место пегилированного липосомального доксорубицина в терапии метастатического рака молочной железы. Опухоли женской репродуктивной системы. 2016;12(2):35-45. https://doi.org/10.17650/1994-4098-2016-12-2-35-45
For citation:
Artamonova E.V. Place of pegylated liposomal doxorubicin in the therapy of metastatic breast cancer. Tumors of female reproductive system. 2016;12(2):35-45. (In Russ.) https://doi.org/10.17650/1994-4098-2016-12-2-35-45
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