Multiple primary synchronous tumor: сancer of the cecum and borderline ovarian tumor with congenital uterine malformation (clinical observation)

A. V. Gerasimov; Герасимов А. В.; S. E. Krasilnikov; Красильников С. Э.; A. G. Kedrova; Кедрова А. Г.; S. A. Fursov; Фурсов С. А.; N. M. Kolotova; Колотова Н. М.; V. E. Voitsitsky; Войцицкий В. Е.

doi:10.17650/1994-4098-2017-13-1-59-63

Multiple primary synchronous tumor: сancer of the cecum and borderline ovarian tumor with congenital uterine malformation (clinical observation)

Authors: Gerasimov A.V.¹, Krasilnikov S.E.¹, Kedrova A.G.², Fursov S.A.¹, Kolotova N.M.¹, Voitsitsky V.E.¹
Affiliations:
1. Novosibirsk State Regional Clinical Oncologic Dispensary
2. Institute for Advanced Training, Federal Medical and Biological Agency
Issue: Vol 13, No 1 (2017)
Pages: 59-63
Section: GYNECOLOGY. ORIGINAL REPORTS
Published: 06.05.2017
URL: https://ojrs.abvpress.ru/ojrs/article/view/536
DOI: https://doi.org/10.17650/1994-4098-2017-13-1-59-63
ID: 536

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Abstract

The article presents a clinical observation of a combination of multiple primary tumors: cancer of the cecum, mixed Müllerian atypical proliferative (borderline) tumors, atypical hyperplasia of the uterus endometrium with uterus didelphys. A rare combination of uterine malformation at the organogenesis stage suggests presence of ectopic Müllerian epithelium in different tissues, where, due to various reasons, notably endometriosis and metabolic disorders, cancerogenic mutations may quickly accumulate. Active metaplasia of ectopic epithelium serves as a favorable medium for microsatellite instability and several pathways of atypical proliferation. This increases the risk of development of multiple
primary tumors.

Keywords

cancer of the cecum, borderline ovarian tumor, surgical treatment, uterus didelphys, mixed Müllerian atypical proliferative (borderline) tumors

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Multiple primary synchronous tumor: сancer of the cecum and borderline ovarian tumor with congenital uterine malformation (clinical observation)

Full Text

Abstract

Keywords

About the authors

A. V. Gerasimov

S. E. Krasilnikov

A. G. Kedrova

S. A. Fursov

N. M. Kolotova

V. E. Voitsitsky

References

Supplementary files