Multiple primary synchronous tumor: сancer of the cecum and borderline ovarian tumor with congenital uterine malformation (clinical observation)
https://doi.org/10.17650/1994-4098-2017-13-1-59-63
Abstract
The article presents a clinical observation of a combination of multiple primary tumors: cancer of the cecum, mixed Müllerian atypical proliferative (borderline) tumors, atypical hyperplasia of the uterus endometrium with uterus didelphys. A rare combination of uterine malformation at the organogenesis stage suggests presence of ectopic Müllerian epithelium in different tissues, where, due to various reasons, notably endometriosis and metabolic disorders, cancerogenic mutations may quickly accumulate. Active metaplasia of ectopic epithelium serves as a favorable medium for microsatellite instability and several pathways of atypical proliferation. This increases the risk of development of multiple
primary tumors.
primary tumors.
About the Authors
A. V. Gerasimov
Novosibirsk State Regional Clinical Oncologic Dispensary
Russian Federation
Russian Federation
S. E. Krasilnikov
Novosibirsk State Regional Clinical Oncologic Dispensary
Russian Federation
Russian Federation
A. G. Kedrova
Institute for Advanced Training, Federal Medical and Biological Agency
Russian Federation
Competing Interests: Department of Obstetrics and Gynecology
Russian Federation
Competing Interests: Department of Obstetrics and Gynecology
S. A. Fursov
Novosibirsk State Regional Clinical Oncologic Dispensary
Russian Federation
Russian Federation
N. M. Kolotova
Novosibirsk State Regional Clinical Oncologic Dispensary
Russian Federation
Russian Federation
V. E. Voitsitsky
Novosibirsk State Regional Clinical Oncologic Dispensary
Russian Federation
Russian Federation
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Review
For citations:
Gerasimov A.V., Krasilnikov S.E., Kedrova A.G., Fursov S.A., Kolotova N.M., Voitsitsky V.E. Multiple primary synchronous tumor: сancer of the cecum and borderline ovarian tumor with congenital uterine malformation (clinical observation). Tumors of female reproductive system. 2017;13(1):59-63. (In Russ.) https://doi.org/10.17650/1994-4098-2017-13-1-59-63
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