Verification of cytological diagnosis of cervical intraepithelial neoplasia using image analysis
https://doi.org/10.17650/1994-4098-2019-15-3-24-31
Abstract
We performed retrospective analysis of cytological and histological smears from 52 women examined and treated in N.N. Petrov National Medical Research Center of Oncology, Ministry of Health of Russia. We have developed a simplified method of densitomorphometry using cytological smears stained with hematoxylin and eosin to verify the diagnosis of cervical intraepithelial neoplasia (CIN). We have identified threshold values for the differentiation between CIN-1/2 and CIN-3: integrated optical density of 4.5 C and percentage of atypical nuclei with a ploidy level ≥5 C of 40 %. The new method verified the morphological diagnosis of CIN in 18 out of 52 patients (34.6 %), including those with discrepant results of cytology and histology. The method can be also used to verify the cytological diagnosis of CIN-3 in patients with negative histology.
About the Author
V. I. Novik
N.N. Petrov National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Competing Interests: not
Russian Federation
68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg 197758
Competing Interests: not
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For citations:
Novik V.I. Verification of cytological diagnosis of cervical intraepithelial neoplasia using image analysis. Tumors of female reproductive system. 2019;15(3):24-31. (In Russ.) https://doi.org/10.17650/1994-4098-2019-15-3-24-31
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