CO2 laser in the diagnostics of resection margins in breast tumors
- Authors: Berishvili A.I.1, Kochoyan T.M.2, Dmitriev A.K.3, Konovalov A.N.3, Ulyanov V.A.3, Kedrova А.G.4
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Affiliations:
- University clinic High technology medical center
- N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
- Institute of Photon Technologies of Federal Scientific Research Centre “Crystallography and Photonics”, Russian Academy of Sciences
- Federal Research and Clinical Center for Specialized Medical Cares and Medical Technologies, Federal Biomedical Agency of Russia
- Issue: Vol 15, No 4 (2019)
- Pages: 23-29
- Section: MAMMOLOGY. ORIGINAL REPORTS
- Published: 12.12.2019
- URL: https://ojrs.abvpress.ru/ojrs/article/view/669
- DOI: https://doi.org/10.17650/1994-4098-2019-15-4-23-29
- ID: 669
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Abstract
To diagnostics of the evaporation of tumor tissue by radiation of single-mode medical CO2 laser is proposed a laser Doppler diagnostic method based on autodyne detection (reception on a laser resonator) of backscattered radiation from the evaporation zone. Intraoperative diagnostics of laser tissue evaporation lets surgeon to determine in real time tumour margins and evaporate it without additional normal tissue traumatization. The sensitivity limits of the method were studied on samples of malignant and benign tumors of breast together with plots of healthy tissue in vitro. It was shown that areas of tumor tissue are well determined by the autodyne method in 80 % of cases.
Keywords
About the authors
A. I. Berishvili
University clinic High technology medical center
Author for correspondence.
Email: aberishvili@yandex.ru
9 Tsinandali St., Tbilisi 0128
Russian FederationT. M. Kochoyan
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
23 Kashirskoe Shosse, Moscow 115478
Russian FederationA. K. Dmitriev
Institute of Photon Technologies of Federal Scientific Research Centre “Crystallography and Photonics”, Russian Academy of Sciences
2 Pionerskaya St., Troitsk 108840
Russian FederationA. N. Konovalov
Institute of Photon Technologies of Federal Scientific Research Centre “Crystallography and Photonics”, Russian Academy of Sciences
2 Pionerskaya St., Troitsk 108840
Russian FederationV. A. Ulyanov
Institute of Photon Technologies of Federal Scientific Research Centre “Crystallography and Photonics”, Russian Academy of Sciences
2 Pionerskaya St., Troitsk 108840
Russian FederationА. G. Kedrova
Federal Research and Clinical Center for Specialized Medical Cares and Medical Technologies, Federal Biomedical Agency of Russia
ORCID iD: 0000-0003-1031-9376
28 Orekhovyy Boulevard, Moscow 115682
Russian FederationReferences
- Pirogova M.S., Letyagin V.P., Peterson S.B. Organ-sparing surgeries in comprehensive treatment of early-stage breast cancer. Opukholi zhenskoy reproduktivnoy sistemy = Tumors of Female Reproductive System 2008;(4):23—6. (In Russ.).
- Fisher B., Anderson S., Bryant J. et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 2002;347:1233-41. doi: 10.1056/NEJMoa022152.
- Veronesi U., Cascinelli N., Mariani L. et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med 2002;347:1227-32. doi: 10.1056/NEJMoa020989.
- Moran M.S., Schnitt S.J., Giuliano A.E. et al. Society of Surgical Oncology-American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer. Ann Surg Oncol 2014;21:704-16. doi: 10.1245/s10434-014-3481-4.
- Lasers in surgery. Ed. by O.K. Skobelkin. Moscow: Meditsina, 1989. 254 p. (In Russ.).
- Dmitriev A.K., Konovalov A.N., Panchenko V.Ya. et al. New approaches to precise and low-traumatic evaporation of tissues using intelligent surgical laser systems. Lazernaya meditsina = Laser Medicine 2013;17(1):4—10. (In Russ.).
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