Level of tumor-infiltrating lymphocytes and PD status as potential prognostic markers of survival and therapy effectiveness in triple-negative breast cancer

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Abstract

In breast cancer, genetic profile and expression of immunohistochemical markers determine prognosis and treatment scheme. Triple-negative breast cancer is characterized by absence of hormone receptor expression and negative HER2 status, as well as high proliferative index. These features of the tumor tissue limit doctors» selection of antitumor drugs. Development of triple-negative variant of tumor tissue is associated with a mutation in the BRCA1/2 gene. Consequently, determination of BRCA1/2 mutations is a prognostic biomarker, and in triple-negative cancer presence of expression of immune checkpoint proteins, multiprotein receptors on the surface of immune cells and tumor tissue play an important role in prognosis and selection of treatment strategy. Additionally, some studies demonstrate existence of multiple prognostic markers which allow to divide patients with triple-negative breast cancer into subgroups facilitating prognosis and selection of treatment strategy.

About the authors

A. F. Nasretdinov

Republican Clinical Oncological Dispensary, Ministry of Health of the Bashkortostan Republic

Russian Federation

N. I. Sultanbaeva

Republican Clinical Oncological Dispensary, Ministry of Health of the Bashkortostan Republic

Russian Federation

Sh. I. Musin

Republican Clinical Oncological Dispensary, Ministry of Health of the Bashkortostan Republic

ORCID iD: 0000-0003-1185-977X
Russian Federation

A. V. Pushkarev

Republican Clinical Oncological Dispensary, Ministry of Health of the Bashkortostan Republic

Russian Federation

K. V. Menshikov

Republican Clinical Oncological Dispensary, Ministry of Health of the Bashkortostan Republic;
Bashkir State Medical University, Ministry of Health of Russia

Russian Federation

V. A. Pushkarev

Republican Clinical Oncological Dispensary, Ministry of Health of the Bashkortostan Republic;
Bashkir State Medical University, Ministry of Health of Russia

Russian Federation

A. V. Sultanbaev

Republican Clinical Oncological Dispensary, Ministry of Health of the Bashkortostan Republic

Author for correspondence.
Email: rkodrb@yandex.ru
ORCID iD: 0000-0003-0996-5995
Александр Валерьевич Султанбаев Russian Federation

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 36991 от  21.07.2009.