Radio-induced breast angiosarcoma: features of diagnostics and treatment (a clinical case and literature review)
https://doi.org/10.17650/1994-4098-2020-16-2-38-43
Abstract
Breast angiosarcoma (BAS) is an extremely rare and poorly studied neoplasm, the etiology of primary BAS remains controversial, and secondary BAS is most often radio-induced. Radio-induced breast tumors usually appear 10–20 years after the initial treatment; however, for BAS this period is much shorter and is about 4–7 years. This review presents literature data on the features of the clinic, diagnosis and treatment of BAS, as well as own clinical case observation of radio-induced sarcoma of the left breast, that developed 4 years after the primary breast cancer treatment.
About the Authors
I. V. Kolyadina
Russian Medical Academy of Postgraduate Education, Ministry of Health of Russia; V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Russian Federation
2 / 1 Barrikadnaya St., Moscow 125993
4 Akademika Oparina St., Moscow 117198
Russian Federation
2 / 1 Barrikadnaya St., Moscow 125993
4 Akademika Oparina St., Moscow 117198
V. V. Kometova
V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Russian Federation
4 Akademika Oparina St., Moscow 117198
Russian Federation
4 Akademika Oparina St., Moscow 117198
Yu. V. Bikeev
V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Russian Federation
4 Akademika Oparina St., Moscow 117198
Russian Federation
4 Akademika Oparina St., Moscow 117198
S. V. Khokhlova
V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Russian Federation
4 Akademika Oparina St., Moscow 117198
Russian Federation
4 Akademika Oparina St., Moscow 117198
V. V. Rodionov
V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Russian Federation
4 Akademika Oparina St., Moscow 117198
Russian Federation
4 Akademika Oparina St., Moscow 117198
References
1. Huang J., Mackillop W.J. Increased risk of soft tissue sarcoma after radiotherapy in women with breast carcinoma.
2. Travis E.L., Kreuther A., Young T. et al. Unusual postirradiation sarcoma of chest wall. Cancer 1976;38:2269–73. DOI: 10.1002/1097-0142(197612)38:6<2269::aid-cncr2820380613>3.0.co;2-7.
3. Fineberg S., Rosen P.P. Cutaneous angiosarcoma and atypical vascular lesions of the skin and breast after radiation therapy for breast carcinoma. Am J Clin Pathol 1994;102(6):757–63. DOI: 10.1093/ajcp/102.6.757.
4. Sessions S.C., Smink R.D. Cutaneous angiosarcoma of the breast after segmental mastectomy and radiation therapy. Arch Surg 1992;127(11):1362–3. DOI: 10.1001/archsurg.1992.01420110114023.
5. Cohen-Hallaleh R.B., Smith H.G., Smith R.C. Radiation induced angiosarcoma of the breast: outcomes from a retrospective case series. Clin Sarcoma Res 2017;7:15. DOI: 10.1186/s13569-017-0081-7.
6. Fant J., Grant M., May S. et al. Angiosarcoma of the breast: Mammographic, clinical, and pathologic correlation. Breast J 2003;9:252–3. DOI: 10.1046/j.1524-4741.2003.09316.x.
7. Ryabchikov D.A., Vorotnikov I.K., Chkhikvadze N.V. et al. Breast sarcomas. Literature review. Tumors of Female Reproductive System 2014;2:12–5. DOI: 10.17650/1994-4098-2014-0-2-12-15.
8. Erel E., Vlachou E., Athanasiadou M. et al. Management of radiation-induced sarcomas in a tertiary referral centre: A review of 25 cases. Breast 2010;19:424–7. DOI: 10.1016/j.breast.2010.04.006.
9. Sheth G.R., Cranmer L.D., Smith B.D. et al. Radiation-induced sarcoma of the breast: a systematic review. Oncologist 2012;17(3):405–18. DOI: 10.1634/theoncologist.2011-0282.
10. Bjerkehagen B., Smeland S., Walberg L. et al. Radiation-induced sarcoma: 25-year experience from the Norwegian Radium Hospital. Acta Oncol 2008;47:1475–82. DOI: 10.1080/02841860802047387.
11. Strobbe L.J., Peterse H.L., van Tinteren H. et al. Angiosarcoma of the breast after conservation therapy for invasive cancer, the incidence and outcome. An unforseen sequela. Breast Cancer Res Treat 1998;47:101–9. DOI: 10.1023/a:1005997017102.
12. Quadros C.A., Vasconcelos A., Andrade R. et al. Good outcome after neoadjuvant chemotherapy and extended surgical resection for a large radiationinduced high-grade breast sarcoma. Int Semin Surg Oncol 2006;3:18. DOI: 10.1186/1477-7800-3-18.
13. Fodor J., Orosz Z., Szabó E. et al. Angiosarcoma after conservation treatment for breast carcinoma: Our experience and a review of the literature. J Am Acad Dermatol 2006;54:499–504. DOI: 10.1016/j.jaad.2005.10.017.
14. Sheth G.R., Cranmer L.D., Smith B.D. et al. Radiation-induced sarcoma of the breast: a systematic review. Oncologist 2012;17(3): 405–18. DOI: 10.1634/theoncologist.2011-0282.
15. Alvarado-Miranda A., Bacon-Fonseca L., Ulises Lara-Medina F. et al. Thalidomide combined with neoadjuvant chemotherapy in angiosarcoma of the breast with complete pathologic response: case report and review of literature. Breast Care (Basel) 2013;8(1):74–6. DOI: 10.1159/000346822.
16. Sleijfer S., Ouali M., van Glabbeke M. et al. Prognostic and predictive factors for outcome to first-line ifosfamidecontaining chemotherapy for adult patients with advanced soft tissue sarcomas: an exploratory, retrospective analysis on large series from the European Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group (EORTC-STBSG). Eur J Cancer 2010;46(1):72–83. DOI: 10.1016/j.ejca.2009.09.022.
17. Neuhaus S.J., Pinnock N., Giblin V. et al. Treatment and outcome of radiation-induced soft-tissue sarcomas at a specialist institution. Eur J Surg Oncol 2009;35(6):654–9. DOI: 10.1016/j.ejso.2008.11.008.
Review
For citations:
Kolyadina I.V., Kometova V.V., Bikeev Yu.V., Khokhlova S.V., Rodionov V.V. Radio-induced breast angiosarcoma: features of diagnostics and treatment (a clinical case and literature review). Tumors of female reproductive system. 2020;16(2):38-43. https://doi.org/10.17650/1994-4098-2020-16-2-38-43
Views:
1400
Email this article 