Successful treatment of high-risk gestational trophoblastic disease in a patient with intolerance to standard chemotherapy (clinical case)
G. M. Teletaeva,
E. A. Ulrikh,
D. Kh. Latipova,
A. I. Semenova,
E. V. Levchenko,
D. G. Ulrikh, 
I. V. Berlev,
T. Yu. Semiglazova,
S. A. Protsenko,
A. F. Urmancheeva
I. V. Berlev,
T. Yu. Semiglazova,
S. A. Protsenko,
A. F. Urmancheeva https://doi.org/10.17650/1994-4098-2020-16-3-67-71
Abstract
Gestational trophoblastic disease is a rare tumor highly sensitive to systemic drug therapy. The standard regimens of chemotherapy of I and II lines for patients in the high-risk group for gestational trophoblastic disease are the EMA-CO, EMA-EP and TP/TE regimens, which have been demonstrated to be effective and require adherence to drug doses and intervals of administration. If these criteria are not met, the risk of developing resistance with an unfavorable outcome for patients is extremely high. The situation is extremely difficult when a patient has an absolute allergic intolerance to one of the components of standard regimens, which is presented in a clinical case.
About the Authors
G. M. Teletaeva
N.N. Petrov National Medical Research Oncology Center, Ministry of Health of Russia
Russian Federation
68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758
Russian Federation
68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758
E. A. Ulrikh
N.N. Petrov National Medical Research Oncology Center, Ministry of Health of Russia; I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia; V.A. Almazov National Medical Research Center, Ministry of Health of Russia
Russian Federation
68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758
41 Kirochnaya St., Saint Petersburg 191015
2 Akkuratova St., Saint Petersburg 197341
Russian Federation
68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758
41 Kirochnaya St., Saint Petersburg 191015
2 Akkuratova St., Saint Petersburg 197341
D. Kh. Latipova
N.N. Petrov National Medical Research Oncology Center, Ministry of Health of Russia
Russian Federation
68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758
Russian Federation
68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758
A. I. Semenova
N.N. Petrov National Medical Research Oncology Center, Ministry of Health of Russia
Russian Federation
68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758
Russian Federation
68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758
E. V. Levchenko
N.N. Petrov National Medical Research Oncology Center, Ministry of Health of Russia; I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia
Russian Federation
68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758
41 Kirochnaya St., Saint Petersburg 191015
Russian Federation
68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758
41 Kirochnaya St., Saint Petersburg 191015
D. G. Ulrikh
Saint Petersburg State Pediatric Medical University
Russian Federation
2 Litovskaya St., Saint Petersburg 194100
Russian Federation
2 Litovskaya St., Saint Petersburg 194100
I. V. Berlev
N.N. Petrov National Medical Research Oncology Center, Ministry of Health of Russia; I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia
Russian Federation
68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758
41 Kirochnaya St., Saint Petersburg 191015
Russian Federation
68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758
41 Kirochnaya St., Saint Petersburg 191015
T. Yu. Semiglazova
N.N. Petrov National Medical Research Oncology Center, Ministry of Health of Russia; I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia
Russian Federation
68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758
41 Kirochnaya St., Saint Petersburg 191015
Russian Federation
68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758
41 Kirochnaya St., Saint Petersburg 191015
S. A. Protsenko
N.N. Petrov National Medical Research Oncology Center, Ministry of Health of Russia
Russian Federation
68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758
Russian Federation
68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758
A. F. Urmancheeva
N.N. Petrov National Medical Research Oncology Center, Ministry of Health of Russia; I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia
Russian Federation
68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758
41 Kirochnaya St., Saint Petersburg 191015
Russian Federation
68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758
41 Kirochnaya St., Saint Petersburg 191015
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For citations:
Teletaeva G.M., Ulrikh E.A., Latipova D.Kh., Semenova A.I., Levchenko E.V., Ulrikh D.G., Berlev I.V., Semiglazova T.Yu., Protsenko S.A., Urmancheeva A.F. Successful treatment of high-risk gestational trophoblastic disease in a patient with intolerance to standard chemotherapy (clinical case). Tumors of female reproductive system. 2020;16(3):67-71. (In Russ.) https://doi.org/10.17650/1994-4098-2020-16-3-67-71
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