Analysis of proteins associated with the expression of cyclooxygenase-2 and the biosynthesis of PGE2 in breast cancer cells with different metastatic potential

V. E. Shevchenko; Шевченко В. Е.; M. A. Taipov; Таипов М. А.; S. V. Kovalev; Ковалев С. В.; N. E. Arnotskaya; Арноцкая Н. Е.; O. M. Pavlova; Павлова О. М.; I. A. Kudryavtsev; Кудрявцев И. А.; Z. N. Nikiforova; Никифорова З. Н.

doi:10.17650/1994-4098-2012-0-3-4-19-28

Analysis of proteins associated with the expression of cyclooxygenase-2 and the biosynthesis of PGE2 in breast cancer cells with different metastatic potential

Authors: Shevchenko V.E.¹, Taipov M.A.¹, Kovalev S.V.¹, Arnotskaya N.E.¹, Pavlova O.M.¹, Kudryavtsev I.A.¹, Nikiforova Z.N.¹
Affiliations:
1. N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Issue: No 3-4 (2012)
Pages: 19-28
Section: MAMMOLOGY. TOPICAL ISSUE
Published: 24.09.2012
URL: https://ojrs.abvpress.ru/ojrs/article/view/110
DOI: https://doi.org/10.17650/1994-4098-2012-0-3-4-19-28
ID: 110

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Abstract

The proteome of lysates of the breast tumor cell lines MCF-7, BT-474, and ZR-75-1 was mapped, resulting in the sequence of 340 proteins. The proteins associated with the biosynthesis of PGE2 and with the regulation of cyclooxygenase-2 expression were identified and their relative expression levels were determined. Potential goals for the targeted therapy of breast cancer, such as prostaglandin E2 and D2 receptors, pros- taglandin E synthase, 15-hydroxyprostaglandin dehydrogenase and leukotriene-A4 -hydrolase, are of special interest in this group.

Keywords

breast cancer, cyclooxygenase-2, prostaglandin E2 and D2 receptors, prostaglandin E synthase, 15-hydroxyprostaglandin dehy- drogenase, leukotriene-A4 -hydrolase, breast tumor cell lines MCF-7, BT-474, ZR-75-1, proteomics, mass spectrometry

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Analysis of proteins associated with the expression of cyclooxygenase-2 and the biosynthesis of PGE2 in breast cancer cells with different metastatic potential

Full Text

Abstract

Keywords

About the authors

V. E. Shevchenko

M. A. Taipov

S. V. Kovalev

N. E. Arnotskaya

O. M. Pavlova

I. A. Kudryavtsev

Z. N. Nikiforova

References

Supplementary files