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Опухоли женской репродуктивной системы

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Анализ белков, ассоциированных с экспрессией циклооксигеназы-2 и биосинтезом PGE2 в клетках рака молочной железы с разным метастатическим потенциалом

https://doi.org/10.17650/1994-4098-2012-0-3-4-19-28

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Аннотация

Проведено картирование протеома лизатов линий опухолевых клеток молочной железы MCF-7, BT-474, ZR-75-1, в результате секвенировано 340 белков. Идентифицированы белки, ассоциированные с биосинтезом PGE2 и регуляцией экспрессии циклоокси- геназы-2, и определены их относительные уровни экспрессии. В данной группе особый интерес представляют потенциальные мишени для направленной терапии рака молочной железы: рецепторы простагландинов E2 , D2 , простагландин Е-синтаза, 15-гид- рокси-простагландиндегидрогеназа и лейкотриен-А4-гидролаза.

Об авторах

В. Е. Шевченко
ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва
Россия


М. А. Таипов
ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва
Россия


С. В. Ковалев
ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва
Россия


Н. Е. Арноцкая
ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва
Россия


О. М. Павлова
ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва
Россия


И. А. Кудрявцев
ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва
Россия


З. Н. Никифорова
ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва
Россия


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Для цитирования:


Шевченко В.Е., Таипов М.А., Ковалев С.В., Арноцкая Н.Е., Павлова О.М., Кудрявцев И.А., Никифорова З.Н. Анализ белков, ассоциированных с экспрессией циклооксигеназы-2 и биосинтезом PGE2 в клетках рака молочной железы с разным метастатическим потенциалом. Опухоли женской репродуктивной системы. 2012;(3-4):19-28. https://doi.org/10.17650/1994-4098-2012-0-3-4-19-28

For citation:


Shevchenko V.E., Taipov M.A., Kovalev S.V., Arnotskaya N.E., Pavlova O.M., Kudryavtsev I.A., Nikiforova Z.N. Analysis of proteins associated with the expression of cyclooxygenase-2 and the biosynthesis of PGE2 in breast cancer cells with different metastatic potential. Tumors of female reproductive system. 2012;(3-4):19-28. (In Russ.) https://doi.org/10.17650/1994-4098-2012-0-3-4-19-28

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ISSN 1994-4098 (Print)
ISSN 1999-8627 (Online)