Molecular biological and ultrasonic methods in the evaluation of the effectiveness of drug therapy in patients with cervical cancer and ovarian cancer
https://doi.org/10.17650/1994-4098-2012-0-3-4-202-203
Abstract
We explored the complex of modern ultrasound technology for dynamic monitoring to assess the effectiveness of drug therapy. This paper analyzes the data of complex clinical, ultrasound and pathological study of 86 patients, was 2 groups of patients – 58 women with locally advanced cervical cancer (IIb–IIIb stages) and 28 patients with ovarian cancer (IIa−IV stages).
During the morphological and ultrasonic parallels found a direct correlation between the degree of drug and the amount pathomorphism tumor focus, a reduction of vascularization and blood flow velocity.
About the Authors
L. A. AshrafyanRussian Federation
I. B. Antonovа
Russian Federation
S. V. Ivashina
Russian Federation
N. A. Babaeva
Russian Federation
A. A. Myagkova
Russian Federation
O. I. Aleshikova
Russian Federation
A. V. Lyustik
Russian Federation
References
1. Давыдов М.И., Аксель Е.М. Злокачественные новообразования в России и странах СНГ в 2000 г. М., 2002. С. 281.
2. Чиссов В.И., Старинский В.В., Петрава Г.В. Состояние онкологической помощи населению России в 2007 г. М.: ФГБУ «МНИОИ им. П.А. Герцена» Минздравсоцразвития России, 2008. 184 с.
3. Чиссов В.И., Старинский В.В., Петрова Г.В. Злокачественные новообразования в России в 2010 г. (заболеваемость и смертность). М.: ФГБУ «МНИОИ им. П.А. Герцена» Минздравсоцразвития России, 2012. С. 260.
4. Тюляндин С.А. Лечение больных распространенным раком яичников. Материалы V ежегодной Российской онкологической конференции. М., 2001. С. 18−20.
5. Benedetti-Panic P., Greggy S., Colombo A. et al. Neoadjuvant Chеmotherapy and Radical Surgery Versus Exclusive Radiotherapy in Locally Advanced Squamous Cell Cervical Cancer: Results From the Italian Multicenter Randomized Study. J Clin Oncol 2002; 20:179−88.
6. Benedetti-Panici P.L., Zullo M.A. Muzii L. et al. The role of neoadjuvant chemotherapy followed by radical surgery in the treatment of locally advanced cervical cancer. Eur J Gynecol Oncol 2003;24(6):467−70.
7. Stewart L.A., Tierney J.F. Neoadjuvant chemotherapy and surgery versus standard radiotherapy for locally advanced cervix cancer: a meta-analysis using individual patient data from randomized controlled trials. Program and abstracts of the American Society of Clinical Oncology 38th Annual Meeting; 2002. Orlando. Florida. Abstract 825.
8. Vasey P. Оn behalf of the Scottish Gynaecological Cancer Trials Group. Survival and longer-term toxicity results of the SCOTROC study: docetaxel-carboplatin (DC) vs. paclitaxel-carboplatin (PC) in epithelial ovarian cancer (EOC). Program and abstracts of the American Society of Clinical Oncology 38th Annual Meeting. 2002. Orlando. Florida. Abstract 804.
9. Гусейнов К.Д. Оценка эффективности использования лекарственной терапии в комбинированном лечении больных раком шейки матки Ib2-III стадий. Дис. ... канд. мед. наук. СПб., 2003. С. 116.
10. Минько Б.А., Михайлова Е.А., Ушакова Г.А. и др. Значение ультразвукового исследования в оценке эффективности химиолучевого лечения рака шейки матки. Невский радиологический форум, 2005. С. 11−2.
11. Greco P., Cormio G., Vimercati A. et al. Transvaginal color Doppler ultrasound for monitoring the response to neoadjuvant chemotherapy in advanced cervical cancer 1997;76:169−72.
Review
For citations:
Ashrafyan L.A., Antonovа I.B., Ivashina S.V., Babaeva N.A., Myagkova A.A., Aleshikova O.I., Lyustik A.V. Molecular biological and ultrasonic methods in the evaluation of the effectiveness of drug therapy in patients with cervical cancer and ovarian cancer. Tumors of female reproductive system. 2012;(3-4):120-125. (In Russ.) https://doi.org/10.17650/1994-4098-2012-0-3-4-202-203