Role of BRCA 1 и BRCA 2 gene mutations in the occurrence of male breast cancer

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Abstract

Particular emphasis has been recently placed on the mechanisms of carcinogenesis in breast cancer (BC), including those in male BC. The paper describes the major risk factors for BC in male patients and covers the role of BRCA1 and BRCA2 gene mutations in the occurrence of this pathology. The most important studies conducted in this area and their results are presented.

About the authors

A. V. Bykova

Research Institute of Clinical Oncology, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow

Russian Federation

I. K. Vorotnikov

Research Institute of Clinical Oncology, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow

Russian Federation

Ya. V. Vishnevskaya

Research Institute of Clinical Oncology, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow

Russian Federation

D. A. Denchik

Research Institute of Clinical Oncology, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow

Russian Federation

L. N. Lyubchenko

Research Institute of Clinical Oncology, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow

Author for correspondence.
Email: clingen@mail.ru
Russian Federation

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