Гены раннего ответа в патогенезе рака шейки матки: обзор
Аннотация
Гены раннего ответа — это группа протоонкогенов, в числе первых активирующихся при стимуляции клетки различными ростовыми факторами и участвующих в регуляции клеточной пролиферации и дифференцировки. Накоплен большой объем данных, подтверждающих, что изменение экспрессии данных генов является одним из центральных и наиболее ранних событий канцерогенеза. В связи с этим представляется перспективным использование генов раннего ответа в качестве диагностических и прогностических маркеров для выявления и комплексной терапии рака шейки матки — одного из наиболее распространенных онко-гинекологических заболеваний, характеризующихся высоким показателем смертности и сложностью ранней диагностики. Теоретическую основу данных перспектив составляют обнаруженные механизмы взаимодействия генов раннего ответа с геномом вируса папилломы человека — главной причиной развития рака шейки матки.
Ключевые слова
Об авторах
О. В. Курмышкина
Петрозаводский государственный университет, Петрозаводск, Карелия
Россия
Россия
Т. О. Волкова
Петрозаводский государственный университет, Петрозаводск, Карелия
Россия
Россия
П. И. Ковчур
Петрозаводский государственный университет, Петрозаводск, Карелия
Россия
Россия
И. Е. Бахлаев
Петрозаводский государственный университет, Петрозаводск, Карелия
Россия
Россия
Н. Н. Немова
Петрозаводский государственный университет;
Институт биологии КарНЦ РАН, Петрозаводск, Карелия
Россия
Россия
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Для цитирования:
Курмышкина О.В., Волкова Т.О., Ковчур П.И., Бахлаев И.Е., Немова Н.Н. Гены раннего ответа в патогенезе рака шейки матки: обзор. Опухоли женской репродуктивной системы. 2011;(1):96-105. https://doi.org/10.17650/1994-4098-2011-0-1-96-105
For citation:
Kurmyshkina O.V., Volkova T.O., Kovchur P.I., Bakhlayev I.E., Nemova N.N. Early response genes in the pathogenesis of cancer of the cervix uteri: a review. Tumors of female reproductive system. 2011;(1):96-105. (In Russ.) https://doi.org/10.17650/1994-4098-2011-0-1-96-105
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