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Опухоли женской репродуктивной системы

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Маммографическая плотность молочных желез и определяющие ее факторы в свете повышенного онкологического риска

https://doi.org/10.17650/1994-4098-2011-0-3-15-22

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Аннотация

Накоплено много данных о том, что высокая маммографическая плотность (МГП) является независимым фактором риска развития рака молочной железы. С учетом этого обстоятельства обобщены данные исследований относительно связи МГП с антропометрическими, гормональными, генетическими и генотоксическими факторами. Отмечена обратная связь МГП с факторами риска — возрастом, числом родов, индексом массы тела и соотношением окружности талии и окружности бедер.
В большинстве исследований установлена прямая связь МГП с уровнем пролактина и инсулиноподобным фактором роста-1 в крови у пациенток пременопаузального возраста. Связь МГП с содержанием в крови эстрогенов, тестостерона, половые гормоны связывающего глобулина, носит неоднозначный характер. Не исключено действие гормонов, особенно эстрогенов, опосредованное через катехолэстрогены и/или свободнорадикальные продукты, ассоциированные с МГП. Имеются определенные доказательства влияния генетического компонента на МГП; в первую очередь это относится к CO MT Val158Met, IGF-I rs6220 A> G и UGT1A1 у пациенток в пременопаузе, а также к ESR1 (XbaI и PvuII) — в периоде менопаузы.
Несмотря на то что на риск развития рака молочной железы, опосредуемый увеличением МГП, оказывают влияние различные факторы, существует необходимость в поиске дополнительных критериев, связанных с этим процессом, а также в выявлении и апробации мер превентивного воздействия.

Об авторах

Д. А. Васильев
ФГУ НИИ онкологии им. Н.Н. Петрова Минздравсоцразвития России, Санкт-Петербург
Россия


А. Н. Зайцев
ФГУ НИИ онкологии им. Н.Н. Петрова Минздравсоцразвития России, Санкт-Петербург
Россия


Л. М. Берштейн
ФГУ НИИ онкологии им. Н.Н. Петрова Минздравсоцразвития России, Санкт-Петербург
Россия


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Для цитирования:


Васильев Д.А., Зайцев А.Н., Берштейн Л.М. Маммографическая плотность молочных желез и определяющие ее факторы в свете повышенного онкологического риска. Опухоли женской репродуктивной системы. 2011;(3):15-22. https://doi.org/10.17650/1994-4098-2011-0-3-15-22

For citation:


Vasilyev D.A., Zaitsev A.N., Berstein L.M. Mammographic density and factors determining it from the point of view of high oncological risks. Tumors of female reproductive system. 2011;(3):15-22. (In Russ.) https://doi.org/10.17650/1994-4098-2011-0-3-15-22

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ISSN 1994-4098 (Print)
ISSN 1999-8627 (Online)