Photodynamic therapy for cutaneous metastases of breast cancer
https://doi.org/10.17650/1994-4098-2011-0-4-28-31
Abstract
Breast cancer is the most common cancer and the leading cause of cancer death in w omen. Cutaneous metastases are observed in 20 % pa- tients with breast cancer. 36 breast cancer patients with cutaneous metastases were treated with photodynamic therapy in the de partment of laser and photodynamic therapy MRRC. Complete regression was obtained in 33.9 %, partial — in 39 % of cases, the stabilization achieved in 25.4 %, progression noted in 1.7 %. The objective response was obtained in 72.9 % of cases, treatment effect — in 97.4 %. Photodynamic therapy has good treatment results of cutaneous metastases of breast cancer with a small number of side effects.
About the Authors
E. V. Goranskaya
Medical Radiological Research Center, Ministry of Health and Social Development of the Russian Federation, Obninsk
Russian Federation
Russian Federation
M. A. Kaplan
Medical Radiological Research Center, Ministry of Health and Social Development of the Russian Federation, Obninsk
Russian Federation
Russian Federation
V. N. Kapinus
Medical Radiological Research Center, Ministry of Health and Social Development of the Russian Federation, Obninsk
Russian Federation
Russian Federation
Y. A. Ragulin
Medical Radiological Research Center, Ministry of Health and Social Development of the Russian Federation, Obninsk
Russian Federation
Russian Federation
E. V. Yaroslavtseva
Medical Radiological Research Center, Ministry of Health and Social Development of the Russian Federation, Obninsk
Russian Federation
Russian Federation
I. S. Spichenkova
Medical Radiological Research Center, Ministry of Health and Social Development of the Russian Federation, Obninsk
Russian Federation
Russian Federation
A. M. Shubina
Medical Radiological Research Center, Ministry of Health and Social Development of the Russian Federation, Obninsk
Russian Federation
Russian Federation
O. V. Borgul
Medical Radiological Research Center, Ministry of Health and Social Development of the Russian Federation, Obninsk
Russian Federation
Russian Federation
M. V. Taibova
Medical Radiological Research Center, Ministry of Health and Social Development of the Russian Federation, Obninsk
Russian Federation
Russian Federation
References
1. Чиссов В.И., Старинский В.В., Петрова Г.В. Состояние онкологической помощи населению России в 2010 году. М., 2011; с. 28.
2. Reynolds T. Photodynamic therapy expands its horizons. J Natl Cancer Inst 1997; 89(2):112–4.
3. Ten Bokkel Huinink W.W. Treatment of skin metastases of breast cancer. Cancer Chemother Pharmacol 1999;(44):31–3.
4. Филинов В.Л. Методика интерстициальной фотодинамической терапии меланомы и рака молочной железы. М., 2004.
5. Clive S., Gardiner J., Leonard R.S.F. Miltefosine as a topical treatment for cutaneous metastases in breast carcinoma. Cancer Chemother Pharmacol 1999;(44):29–30.
6. Gehl J., Matthiessen L.M., Humphreys A. Management of cutaneous metastases by electrochemotherapy. J Clin Oncol 2010;(28):15.
7. Странадко Е.Ф. Механизмы действия фотодинамической терапии. Рос онкол журн 2008;4(4):52.
8. Dougherty T.J. An update on photodynamic therapy applications. J Clin Laser Med Surg 2002;20(1):3–7.
9. Huang Z., Xu H., Meyers A.D. et al. Photodynamic therapy for treatment of solid tumors — potential and technical challenges. Technol Cancer Res Treat 2008;7(4):309–20.
10. Anderson C., Hrabovsky S., McKinley Y. et al. Phthalocyanine photodynamic therapy disparate effects of pharmacological ingibitors on cutaneous photosensitivity and on tumour regression. J Photochem Photobiol 1997; 65(5):895–901.
11. Castano A.P., Mroz P., Hamblin M.R. Photodynamic therapy and antitumour immunity. Nat Rev Cancer 2006; (6):535–45.
12. Taber S.W., Fingar V.H., Wieman T.J. Photodynamic therapy for palliation of chest wall recurrence in patients with breast cancer. J Surg Oncol 1988;68(4):209–14.
13. Wyss P., Schwarz V., Dobler-Girdziunaite D. et al. Photodynamic therapy of locoregional breast cancer recurrences using a chlorin-type photosensitizer. Int J Cancer 2001;(93):720–4.
14. Вакуловская Е.Г. Фотодинамическая терапия и флюоресцентная диагностика опухолей. М., 2006.
15. Allison R., Mang T., Hewson G. et al. Photodynamic therapy for chest wall progression from breast carcinoma is an underutilizet treatment modality. Cancer 2001;91(1):1–8.
16. Cuenca R.E., Ron R., Allison R.R. et al. Breast cancer with chest wall progression: treatment with photodynamic therapy. Ann Surg Oncol 2004;11(3):322–7.
Review
For citations:
Goranskaya E.V., Kaplan M.A., Kapinus V.N., Ragulin Y.A., Yaroslavtseva E.V., Spichenkova I.S., Shubina A.M., Borgul O.V., Taibova M.V. Photodynamic therapy for cutaneous metastases of breast cancer. Tumors of female reproductive system. 2011;(4):28-31. (In Russ.) https://doi.org/10.17650/1994-4098-2011-0-4-28-31
Views:
802
Email this article 