Comparative characterization of oxidative stress in cervical cancer at different clinical stages of disease
https://doi.org/10.17650/1994-4098-2011-0-4-55-58
Abstract
Parameters of oxidative stress on the level of malondialdehyde (MDA), activity of glutathione-reductase, glutathione-transferase, superoxide- dismutase (SOD) and catalase in tumor tissue, plasma and red blood cells of patients with cervical cancer (CC) w as evaluated a t various clinical stages of the disease. It is revealed that an increase in tumor tissue MD A and glutathione enzymes while reducing SOD and catalase, which may indicate the development of oxidative stress in the dynamics of tumor progression. The data obtained suggest the increase of expres- sion of oxidative stress in red blood cells and tumor tissue in CC in the dynamics of tumor progression.
About the Authors
I. I. Antoneeva
Ulyanovsk State University
Russian Federation
Russian Federation
T. P. Gening
Ulyanovsk State University
Russian Federation
Russian Federation
D. R. Arslanova
Ulyanovsk State University
Russian Federation
Russian Federation
E. G. Sidorenko
Ulyanovsk State University
Russian Federation
Russian Federation
References
1. Бебнева Т.Н., Прилепская В.К. Папилломавирусная инфекция и рак шейки матки. Практ гинекол 2001; 3(3):77–82.
2. Parkin D.M., Bray F., Ferlay J., Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005;55(2):74–108.
3. Писарева Л.Ф., Бояркова А.П., Коюкова Е.В., Коюкова Т.В. Особенности заболеваемости раком шейки матки населения Читинской области. Сиб онкол журн 2010; 6(42):42–7.
4. Чиссов В.И., Старинский В.В., Петрова Г.В. Злокачественные ново-образования в России в 2002 г. (заболеваемость и смертность). М., 2004.
5. Меньщикова Е.Б., Зенков Н.К., Ланкин В.З. и др. Окислительный стресс. Патологические состояния и заболевания. Новосибирск: АРТА, 2008.
6. Linnane A.W., Kios M., Vitetta L. Healthy aging: regulation of the metabolome by cellular redox modulation and prooxidant signaling systems: the essential roles of superoxide anion and hydrogen peroxide. Biogerontology 2007t;8(5):445–67.
7. Ляхович В.В., Вавилин В.А., Зенков Н.К., Меньшикова Е.Б. Активная защита при окислительном стрессе. Антиоксидант — респонсивный элемент. Биохимия 2006;71(9):1183–97.
8. Андреева Л.И., Кожемякин Л.А., Кишкун А.А. Модификация метода определения перекисей липидов в тесте с тиобарбитуровой кислотой. Лаб дело 1988;(11):41–3.
9. Карпищенко А.И. Медицинские лабораторные технологии и диагностика. Справочник в 2 т. СПб.: Интермедика, 1999. Т.2; с. 27–30.
10. Nishikimi M., Appa N., Yagi K. The occurrence of superoxide anion in the reaction of reduced phenacine methosulfate and molecular oxygen. Biochem Biophys Res Commun 1972;46:849–54.
11. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248–54.
Review
For citations:
Antoneeva I.I., Gening T.P., Arslanova D.R., Sidorenko E.G. Comparative characterization of oxidative stress in cervical cancer at different clinical stages of disease. Tumors of female reproductive system. 2011;(4):55-58. (In Russ.) https://doi.org/10.17650/1994-4098-2011-0-4-55-58
Views:
617
Email this article 