Identification of proteomic markers for metastasis of ovarian cancer

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Abstract

The proteome of ascites and pleural fluids (AF and PF) was mapped in patients with ovarian cancer (OC). 240 and 190 proteins were identi- fied with a high degree of assurance in A F and PF, respectively . The major portion w as extracellular and membrane proteins, whi ch ac- counted for 45 and 49 % in AF and PF, respectively. Analysis of the proteomic maps of AF and PF indicated that 82 proteins were common to these biological fluids whereas 81 and 49 proteins were unique to A F and PF, respectively. A list of 46 potential markers for O C metastasis and potential markers for tropic OC metastasis over the peritoneal (17 proteins) and pleural (11 proteins) surfaces is given.

About the authors

V. E. Shevchenko

Oncoproteomics Laboratory N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow

Author for correspondence.
Email: vshev@nm.ru
Russian Federation

D. E. Makarov

Oncoproteomics Laboratory N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow

S. V. Kovalev

Oncoproteomics Laboratory N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow

N. E. Arnotskaya

Oncoproteomics Laboratory N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow

N. R. Pogosyan

Gynecology Department N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow

K. I. Zhordania

Gynecology Department N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow

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