Non-invasive optical method for evaluating the oxygen status in breast neoplasms
https://doi.org/10.17650/1994-4098-2010-0-1-5-10
Abstract
The paper presents the results from a study of the breast oxygen status by diffuse optical tomography (DOT). Detection of breast tissue at wavelengths of 684, 794, and 850 nm could provide information on the distribution of basic tissue chromophores: oxygenized and deoxygenized hemoglobin. Normal breast tissue was characterized by the even distribution of these compounds and stabilization of their level. In breast cancer, the distribution of oxy- and deoxyhemoglobin was noted for uneven distribution and blood oxygen saturation was lower in the projection of a tumor nodule. The blood oxygen saturation data obtained by DOT demonstrate physiological differ- ences between normal and tumor tissues in different tumor areas.
About the Authors
A. V. Maslennikova
Nizhni Novgorod State Medical Academy;
Institute of Applied Physics, Russian Academy of Sciences, Nizhni Novgorod
Russian Federation
Russian Federation
G. Yu. Golubyatnikov
Institute of Applied Physics, Russian Academy of Sciences, Nizhni Novgorod
Russian Federation
Russian Federation
A. G. Orlova
Institute of Applied Physics, Russian Academy of Sciences, Nizhni Novgorod
Russian Federation
Russian Federation
V. I. Plekhanov
Institute of Applied Physics, Russian Academy of Sciences, Nizhni Novgorod
Russian Federation
Russian Federation
A. A. Artifeksova
Nizhni Novgorod State Medical Academy;
Institute of Applied Physics, Russian Academy of Sciences, Nizhni Novgorod
Russian Federation
Russian Federation
N. M. Shakhova
Nizhni Novgorod State Medical Academy;
Institute of Applied Physics, Russian Academy of Sciences, Nizhni Novgorod
Russian Federation
Russian Federation
V. A. Kamensky
Institute of Applied Physics, Russian Academy of Sciences, Nizhni Novgorod
Russian Federation
Russian Federation
I. V. Turchin
Institute of Applied Physics, Russian Academy of Sciences, Nizhni Novgorod
Russian Federation
Russian Federation
References
1. Явишева Т.М., Щербаков С.Д., Савлучинская Л.А. Особенности работы морфофункциональных зон в нормальном эпителии, фиброаденоме и раке молочной железы. Докл Акад Наук 2005;404(1):125—8.
2. Кушлинский Н.Е., Герштейн Е.С. Современные возможности молекулярно-биохимических методов оценки биологического «поведения» рака молочной железы. Вестн РАМН 2001;9:65—70.
3. Vaupel P. Hypoxia and aggressive tumor phenotype: Implications for thera- py and prognosis. Oncologist 2008;13(Suppl 3):21—6.
4. Vaupel P., Kallinowski F., Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 1989;49:6449—65.
5. Horsman M.R., Overgaard J. The oxygen effect and tumor microenvi- ronment. In: Basic clinical radiobiology. G.G. Steel, ed. London: Arnold, 2002. p. 58—168.
6. Horsman M.R., Overgaard J. Preclinical studies on how to deal with patients intolerance to nicotine and car- bogen. Radiother Oncol 2004;70:301—9.
7. Koritzinsky M., Seigneuric R., Magagnin M.G. et al. The hypoxic pro- teome is influenced by gene-specific changes in mRNA translation. Radiother Oncol 2005;76:177—86.
8. Sorensen B.S., Hao J., Overgaard J. et al. Influence of oxygen concentration and pH on expression of hypoxia induced genes. Radiother Oncol 2005;76:187—93.
9. Nordsmark M., Bentzen S.M., Rudat V. et al. Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An inter- national multi-center study. Radiother Oncol 2005;77:18—24.
10. Höckel M., Schlenger K., Aral B. et al. Association between tumor hypoxia and malignant progression in advanced cancer of uterine cervix. Cancer Res 1996;56:4509—15.
11. Yaromina A., Zips D., Thames H.D. et al. Pimonidazole labelling and response to fractionated irradiation of five human squamous cell carcinoma (hSCC) lines in nude mice: The need for a multivariative approach in biomarker studies. Radiother Oncol 2006;81(2):122—9.
12. Kelleher D.K., Thews O., Vaupel P. Hypoxyradiotherapy — lack of experi- mental evidence for preferential radio- protective effect on normal versus tumor tissue as shown by direct oxygenation measurements in experimental sarcomas. Radiother Oncol 1997;45:191—7.
13. Sergeev A.M., Dolin L.S., Reitze D.H. Review on optical tomogra- phy of biotissues. Oрtical tomography of biotissues past, present, and future. Opt Photon News 2001;July:328—53.
14. Тучин В.В. Лазеры и волоконная оптика в биомедицинских исследованиях. Саратов: Изд-во Саратовского ун-та, 1998.
15. McBride T.O., Pogue B.W., Poplack S. et al. Multispectral near- infrared tomography: a case study in compensating for water and lipid content in hemoglobin imaging of the breast. J Biomed Opt 2002;7(1):72—9.
16. Jiang H., Xu Y., Ifitimia N. et al. Three dimensional optical tomographic imaging of breast in a human subject. IEEE Trans Med Imag 2001;20:1334—40.
17. Orlova A.G., Turchin I.V., Plehanov V.I. et al. Frequency-domain diffuse optical tomography with single source-detector pair for breast cancer detection. Laser Phys Lett 2008;5(4):321—7.
18. Torricelli A., Spinelli L., Pifferi A., et al. Use of a nonlinear perturbation approach for in vivo breast lesion charac- terization by multiwavelength time- resolved optical mammography. Opt Express 2003;11(8):853—67.
19. Thomsen S., Tatman D. Physiological and pathological factors of human breast disease that can influence optical diagnosis. Ann NY Acad Sci 1998;838:171—93.
20. Vaupel P., Mayer A., Briest S. et al. Oxygenation gain factor: a novel parame- ter characterizing the association between hemoglobin level and the oxygenation status of breast cancers. Cancer Res 2003;63:7634—7.
Review
For citations:
Maslennikova A.V., Golubyatnikov G.Yu., Orlova A.G., Plekhanov V.I., Artifeksova A.A., Shakhova N.M., Kamensky V.A., Turchin I.V. Non-invasive optical method for evaluating the oxygen status in breast neoplasms. Tumors of female reproductive system. 2010;(1):5-10. (In Russ.) https://doi.org/10.17650/1994-4098-2010-0-1-5-10
Views:
568
Email this article 