5-PGDH expression in breast cancer cells

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Abstract

This paper analyzes 15-PGDH gene expression in the human breast cancer (BC) cell liness and describes the molecular principles through which the expression of the enzyme 15-PGDH is controlled in the tumor cells with a varying metastatic potential. There is an inverse correla- tion of 15-PGDH gene expression with COX-2 expression and the metastatic potential of tumor cells. Investigation of mechanisms for 15-PGDH regulation opens up new vistas and possibilities for the design of effective drugs for the targeted therapy of metastatic forms of BC.

About the authors

M. A. Taipov

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow

Author for correspondence.
Email: taipoff.m@yandex.ru
Russian Federation

Z. N. Nikiforova

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow

Russian Federation

O. M. Pavlova

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow

Russian Federation

I. A. Kudryavtsev

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow

Russian Federation

N. Ye. Arnotskaya

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow

Russian Federation

V. Ye. Shevchenko

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow

Russian Federation

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