Preview

Опухоли женской репродуктивной системы

Расширенный поиск

Лучевая терапия после органосохраняющих операций на молочной железе

https://doi.org/10.17650/1994-4098-2014-0-2-23-29

Полный текст:

Аннотация

В статье приводятся основные современные данные, касающиеся наиболее оптимального применения лучевой терапии после ор- ганосохраняющих операций на молочной железе. Обсуждаются показания и противопоказания использования метода в различных возрастных категориях, а также при различных прогностических факторах.

Об авторах

И. А. Гладилина
ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва
Россия


М. И. Нечушкин
ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва
Россия


В. А. Уйманов
ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва
Россия


И. В. Высоцкая
ГБОУ ВПО Первый МГМУ им. И.М. Сеченова Минздрава России
Россия


М. В. Черных
ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва
Россия


А. В. Егорова
ГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва
Россия


С. В. Чулкова
ГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва
Россия


Список литературы

1. Arriagada R., Lê M.G., Rochard F., Contesso G. Conservative treatment versus mastectomy in early breast cancer: patterns

2. of failure with 15 years of follow-up data. Institut Gustave-Roussy Breast Cancer Group. J Clin Oncol 1996;14(15):1558–64.

3. Clark R.M., McCulloch P.B., Levine M.N. et al. Randomized clinical trial to assess

4. the effectiveness of breast irradiation following lumpectomy and axillary dissection for node- negative breast cancer J Natl Cancer Inst 1992;84(9):683–9.

5. Fisher B., Anderson S., Bryant J. et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 2002;347(8):1233–41.

6. Veronesi U., Cascinelli N., Mariani L. et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer.

7. N Engl J Med 2002;347(16):1227–32.

8. Клиническая онкология. Под ред. Н.Н. Блохина, Б.Е. Петерсона. 2-е изд. М.: Медицина, 1979.

9. Вишнякова В.В. Эффективность эко- номных операций при раке молочной железы. Вопр онкол 1990;36(5):540–5.

10. Практическое руководство по клиниче- ской маммологии. Под ред. М.И. Давыдо- ва, В.П. Летягина. М., 2004. С. 59–62.

11. Давыдов М.И., Летягин В.П. Семинар по клинической маммологии. М., 2006. С. 59–63.

12. Высоцкая И.В., Кушлинский Н.Е., Погодина Е.М. и др. Практическая маммо- логия. Под ред. М.И. Давыдова, В.П. Летягина. М., 2007. 272 с.

13. Первичные опухоли молочной железы. Практическое руководство по лечению. Под ред. В.П. Летягина. М., 2004. 330 с.

14. Gilligan M.A., Kneusel R.T., Hoffmann R.G. Persistent differences in sociodemographic determinants of breast conserving treatment despite overall increased adoption. Med Care 2005;40(3):181–9.

15. Johansson S., Svensson H., Denekamp J. Timescale of evolution of late radiation injury after postoperative radiotherapy of breast cancer patients. Int J Radiat Oncol Biol Phys 2000;48(3):745–50.

16. Veronesi U., Luini A., Del Vecchio M. et al. Radiotherapy after breast-preserving surgery in women with localized cancer of the breast. N Engl J Med 1993;328(22):1587–91. 14. Antonini N., Jones H., Horiot J.C. et al. Effect of age and radiation dose on local control after breast conserving treatment: EORTC trial 22881–10882. Radiother Oncol 2007;82(3):265–71.

17. Foote R.L., Johnson R.E., Donohue J.H. et al. Trends in surgical treatment of breast cancer at Mayo Clinic 1980–2004. Breast 2008;17(6):555–62.

18. Morrow M., White J., Moughan J. et al. Factors predicting the use of breast-conserving therapy in stage I and II breast carcinoma. Am J Clin Oncol 2001;19(8):2254–62.

19. National Comprehensive Cancer Network. Breast cancer. NCCN clinical practice guidelines in oncology: Version 3.2012. http:// www.nccn.org/professionals/physician_gls.

20. Pezner R.D., Wagman L.D., Ben-Ezra J., Odom-Maryon T. Breast conservation therapy: local tumor control in patients with pathologically clear margins who receive 5000 cGy breast irradiation without local boost. Breast Cancer Res Treat 1994;32(3):261–7.

21. Polednak A.P. Trends in, and predictors of, breast-conserving surgery and radiotherapy for breast cancer in Connecticut, 1988–1997. Int J Radiat Oncol Biol Phys 2002;53(1):157–6.

22. Shafiq J., Delaney G., Barton M.B. An evidence-based estimation of local control and survival benefit of radiotherapy for breast cancer. Radiother Oncol 2007;84(1):11–7.

23. Yarnold J., Ashton A., Bliss J. et al. Fractionation sensitivity and dose response of late adverse effects in the breast after radiotherapy for early breast cancer: long-term results of a randomized trial. Radiother Oncol 2005;75(1):9–17.

24. Van Nes J.G.H., van de Velde C.J.H. The preferred treatment for young women with breast cancer – mastectomy versus breast conservation. Breast 2006;15(Suppl 2): 3–10.

25. Silva O.T., Zurrida S. Breast сancer: а practical guide. 3th ed. NY: Elsevier, 2005. Рр. 171–83.

26. Kunos C., Latson L., Overmoyer B. et al. Breast conservation surgery achieving > or = 2 mm tumorfree margins results in decreased local regional recurrence rates. Breast J 2006;12(1):28–36.

27. van Dongen J.A., Bartelink H., Fentiman I.S. et al. Randomized clinical trial to assess the value of breast conserving therapy in stage I and stage II breast cancer, EORTC 10801 trial. J Natl Cancer Inst Monogr 1992;(11):15–8.

28. Golhirsch A., Ingle J.N., Gelber R.D. et al. Thresholds for therapies: highlights

29. of the St Gallen International Expert Consensus on the рrimary therapy of early breast cancer. Ann Oncol 2009;20(8): 1319–29.

30. Begg A., van der Kogel A. Clinical radiobiology in 2008. Radiother Oncol 2008;86(3):295–9.

31. Budach W., Fourquet A., Poortmans P. Recent advances in breast cancer radiotherapy. Eur J Cancer Suppl 2008;6(7):13–4.

32. NCCN GuidelinesTM Version 2.2011, Р. 38; NSABP Clinical Trials Overview, Protocol B-39/RTOG (in press). http://www.nsabp.pitt. edu.

33. Pignol J., Olivotto I., Rakovitch E. et al. Plenary 1: Phase III randomized study of intensity modulated radiation therapy versus standard wedging technique for adjuvant breast radiotherapy. Int J Radiat Oncol Biol Phys 2006;66(3 Suppl):1.

34. Fourquet A., Campana F., Rosenwald J. et al. Breast irradiation in the lateral decubitus position technique of the Institute Curie. Radiother Oncol 1991;22(4):261–5.

35. Donovan E. Randomized trial of standard 2D radiotherapy (RT) versus intensity modulated radiotherapy (IMRT) in patients prescribed breast radiotherapy. Radiother Oncol 2007;82(3):254–64.

36. Mathew J., Barthelmes L., Neminathan S. et al. Comparative study of lymphoedema with axillary node dissection versusaxillary node sampling with radiotherapy in patients undergoing breast conservation surgery. Eur J Surg Oncol 2006;32(7):729–32.

37. Pignol J.P., Olivotto I., Rakovitch E. et al. A multicenter randomized trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitis. J Clin Oncol 2008;26(13):2085–92.

38. Bartelink H., Horiot J.C., Poortmans P. et al. Recurrence rates after treatment of breast cancer with standard radiotherapy with or without additional radiation. N Engl J Med 2001;345(19):1378–87.

39. Brady L.W., Heilmann H.P., Molls M., Nieder C. Radiation оncology: аn еvidence- based approach. Medical radiology. 2008. Р. 11–127.

40. Clarke M., Collins R., Darby S. et al. Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival. An overview of the randomized trials. Lancet 2005;366(9503):2087–106.

41. Favorable and unfavorable effects on long- term survival of radiotherapy for early breast cancer: an overview of the randomized trials. Early Breast Cancer Trialists’ Collaborative Group. Lancet 2000;355(9217):1757–70.

42. Hepel J.T., Tokita M., MacAusland S.G. et al. Toxicity of three-dimensional conformal radiotherapy for accelerated partial breast irradiation. Int J Radiat Oncol Biol Phys 2009;75(5):1290–6.

43. Van Dongen J.A., Bartelink H., Fentiman I.S. et al. Factors influencing local relapse and survival and results of salvage treatment after breast-conserving therapy in operable breast cancer: EORTC trial 10001, breast conservation compared with mastectomy in TNM stage I and II breast cancer. Eur J Cancer 1992;28:801–5.

44. Whelan T.J., Julian J., Wright J. et al. Does loko-regional radiational therapy improve survival in breast cancer? A meta- analysis. J Clin Oncol 2000;18(6):1220–9.

45. Freedman, G.M., Anderson P.R., Goldstein L.J. et al. Four-week course of radiation for breast cancer using hypofractionated intensity modulated radiation therapy with an incorporated boost. Int J Radiat Oncol Biol Phys 2007;68(2):347–53. 43. Golhirsch A., Glick J.H., Gelber R.D.

46. et al. Meeting highlights: international expert consensus on the primary therapy of early breast cancer. ESO – Moscow breast cancer forum. 2005. Pp. 3–17.

47. Louis-Sylvestre C., Clough K.B., Falcou M.C. et al. Radiotherapy for early breast cancer: 15 year results. 2001. Pp. 10–3. 45. Veronesi U., Luini A., Galimberti V. Zurrida S. Conservation approaches for the management of stage I/II carcinoma of the breast. Milan Cancer Institute trials World. J Surg 1994;18(1):70–5.

48. Boecker W., Löchnert C., Korsching E. Differential expression of ER and Ki67 in normal breast tissue and proliferating breast disease: further support of the progenitor cell concept? Eur J Cancer 2007;3(5):4–5.

49. Mannino M., Yarnold J.R. Local relapse rates are falling after breast conserving surgery and systemic therapy for early breast cancer: сan radiotherapy ever be safely withheld? Radiother Oncol 2009;90(1):14–22.

50. Truong P.T., Bernstein V., Lesperace M. et al. Radiotherapy omission after breast- conserving surgery is associated with reduced breast cancer-specific survival in elderly women with breast cancer. Am J Surg 2006;191(6):749–55.

51. Winzer K.J., Sauer R., Sauerbrei W. et al.; German Breast Cancer Study Group. Radiation therapy after breast-conserving surgery: randomized trial in patients with low risk of recurrence. Eur J Cancer 2004;40(7):998–1005.

52. Voordeckers G., Van de Steene J., Vinh-Hung V., Storme G. et al. Adjuvant radiotherapy after mastectomy for pT1-pT2 node negative (pN0) breast cancer: is it worth the effort? Radiother Oncol 2003;68(3): 227–31.

53. Borgen P.I., Sacchini V., Zurrida S. et al. Local control matters breast diseases. A Year Book Quarterly 2006;17(3):210–2.

54. Breast surgical techniques and interdisciplinary management. F.M. Dirbas, E.H. Carol, еds. Springer Science + Business Media, 2011. Рр. 813–28.

55. Fyles A.W., McCready D.R., Manchul L.A. et al. Tamoxifen with or without breast irradiation in women 50 years of age or older with early breast cancer. N Engl J Med 2004;351(10):963–70.

56. Hughes K.S., Schnaper L.A., Berry D. et al. Lumpectomy plus tamoxifen with

57. or without irradiation in women 70 years of age or older with early breast cancer. N Engl J Med 2004;351(10):971–7.

58. Bartelink H. Impact of a higher radiation dose on local control and survival in breast- conserving therapy of early breast cancer: 10-year results of the Randomized Boost Versus No Boost EORTC 22881–10882 Trial. J Clin Oncol 2007;25(22):3259–65.

59. Jones H., Antonini N., Colette L. et al. The impact of boost dose and margins on the local recurrence rate in breast conserving therapy: results from the EORTC boost-no boost trial. Int J Radiat Oncol Biol Phys 2007;69(Suppl 1):S2–3.

60. Bantema-Joppe E.J., van der Laan H.P., Maduro J.H. et al. Phase I-II trial of prone accelerated intensity modulated radiation therapy to the breast to optimally spare normal tissue. Radiat Oncol 2011;100:215–20.

61. Bantema-Joppe E.J., Schilstra C., de Bock G.H. et al. Tree-dimentional conformal simultaneously integrated boost technique for breast-conserving therapy: results on local control and survival. Int J Radiat Oncol Biol Phys 2012;83:471–7.

62. Hurkmans C.W., Meijer C.J., van Vliet-Vroegindeweij C. et al. High-dose simultaneosly intergated breast boost using intensity-modulated radiotherapy and inverse optimization. Int J Radiation Oncol Biol Phys 2006;66(3):923–30.

63. Singla R., King S., Albuquerque K. et al. Simultaneous-integrated boost intensity- modulated radiation therapy (SIB-IMRT) in the treatment of early-stage left-sided breast carcinoma. Med Dosim 2006;31(3):190–6.

64. van der Laan H.P., Dolsma W.V., Maduro J.H. et al. Three-dimensional conformal simultaneously integrated boost technique

65. for breast-conserving radiotherapy. Int J Radiat Oncol Biol Phys 2007;68(4):1018–23.

66. Guerrero M., Li X.A., Earl M.A. et al. Simultaneous integrated boost for breast cancer using IMRT: a radiobiological and treatment planning study. Int J Radiat Oncol Biol Phys 2004;59(5):1513–22.

67. Freedman G.M., White J.R., Artur D.W., Li X.A. et al. Accelerated fractionation with

68. a concurrent boost for early stage breast cancer. Radiat Oncol 2013;106: 15–20.

69. McDonald M.W., Godette K.D., Whitaker D.J. et al. Three-year outcomes

70. of breast intensity-modulated radiation therapy with simultaneous integrated boost. Int

71. J Radiat Oncol Biol Phys 2010;77(2):523–30. 65. James M.L., Lehman M., Hider P.N. et al. An evidence-based estimation of local control and survival benefit of radiotherapy for breast cancer. Radiother Oncol 2007;84(1):11–7.

72. Truong P.T., Jones S.O., Kader H.A. et al. Patients with T1 to T2 breast cancer with one to three positive nodes have higher local and regional recurrence risks compared with node- negative patients after breast-conserving surgery and whole-breast radiotherapy international. J Radiat Oncol Biol Phys 2009;73:357–64.

73. Ahn P.H., Vu H.T., Lannin D. et al. Sequence of radiotherapy with tamoxifen

74. in conservatively managed breast cancer does not affect local relapse rates. J Clin Oncol 2005;23(1):17–23.

75. Harris E.E., Christensen V.J., Hwang W.T. et al. Impact of concurrent versus sequential tamoxifen with radiation therapy in early-stage breast cancer patients undergoing breast conservation treatment. J Clin Oncol 2005;23(1):11–23.

76. Pierce L.J., Hutchins L.F., Green S.R. et al. Sequencing of tamoxifen and radiotherapy after breast-conserving surgery in early-stage breast cancer. J Clin Oncol 2005;23(1):24–9.


Для цитирования:


Гладилина И.А., Нечушкин М.И., Уйманов В.А., Высоцкая И.В., Черных М.В., Егорова А.В., Чулкова С.В. Лучевая терапия после органосохраняющих операций на молочной железе. Опухоли женской репродуктивной системы. 2014;(2):23-29. https://doi.org/10.17650/1994-4098-2014-0-2-23-29

For citation:


Gladilina I.A., Nechushkin M.I., Uimanov V.А., Vysotskaya I.V., Chernykh M.V., Yegorova A.V., Chulkova S.V. Radiotherapy following organ-sparing surgery for breast cancer. Tumors of female reproductive system. 2014;(2):23-29. (In Russ.) https://doi.org/10.17650/1994-4098-2014-0-2-23-29

Просмотров: 188


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 1994-4098 (Print)
ISSN 1999-8627 (Online)