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Comparative analysis of parasternal lymph collector exposures in the organ-sparing treatment of patients with operable breast cancer

https://doi.org/10.17650/1994-4098-2010-0-2-31-35

Abstract

The paper presents the results of a follow-up of 593 patients with the internal and central localization of clinical stages I-IIb breast cancer whose treatment comprises parasternal treatment techniques: teleradiotherapy (TRT), intratissue radiotherapy (ITRT), and video-assisted thoracoscopic parasternal lymphadenectomy (VAPL). A control group included 846 patients with the external localiza- tion of a tumor. There was a statistically significant increase in 5-year overall (98.2%) and relapse-free (96.2%) survival rates in Stage I in the VAPL versus TRT and ITRT groups (overall survival, 92.5 and 89.7%; relapse-free survival, 80.8 and 73.4%, respectively) (p < 0.05). There was no difference in survival rates between the study and control groups. It is concluded that VAPL permits the objective staging of the disease and any therapeutic exposure of the parasternal area made survival rates similar in the study and control groups.

About the Authors

V. A. Uimanov
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Russian Federation


A. V. Trigolosov
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Russian Federation


M. I. Nechushkin
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Russian Federation


I. A. Gladilina
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Russian Federation


References

1. Veronesi U., Cascinelli N., Mariani L. et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med 2002;347(16):1217–32.

2. Colleoni M., Zahrieh D., Gelber R.D. et al. Site of primary tumor has a prognostic role in operable breast cancer: the international breast cancer study group experience. J Clin Oncol 2005;23(7):1390–400.

3. Gaffney D.K., Tsodikov A., Wiggins C.L. Diminished survival in patients with inner versus outer quadrant breast cancers. J Clin Oncol 2003;21:467–72.

4. Lohrisch С., Jackson J., Jones A. et al. Relationship between tumor location and relapse in 6,781 women with early invasive breast cancer. J Clin Oncol 2000;18:2828–35.

5. Zucali R., Mariani L., Marubini E. et al. Early breast cancer: Evaluation of the prognostic role of the site of

6. the primary tumor. J Clin Oncol 1998;16:1363–6.

7. Триголосов А.В., Нечушкин М.И., Уйманов В.А. и др. Поражение внутренних грудных лимфатических узлов при раке молочной железы: результаты 1026 видеоторакоскопических парастернальных лимфаденэктомий. Маммология 2007;(1):25–32.

8. Freedman G.M., Fowble B.L., Nicolaou N. et al. Should internal mammary lymph nodes in breast cancer be a target for the radiation oncologist? Int J Radiat Oncol Phys 2000;46:805–14.

9. Handly R.S., Thackray A.C. The internal mammary lymph chain in carcinoma of the breast. Lancet 1949;(2):267–8.

10. Veronesi U., Cascinelli N., Mariani L. et al. Twenty-year follow- up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med 2002;347(16):1217–32.

11. Сущихина М.А. Радиобиологическое и дозиметрическое планирование контактной лучевой терапии злокачественных новообразований: Дис. ... канд. биол. наук. М., 1995.

12. Van Limbergen E. Indications and technical aspects of brachytherapy in breast conserving treatment of breast cancer. Cancer Radiother 2007;7:107–20.

13. Нечушкин М.И. Лечение больных раком молочной железы центральной и медиальной локализации с использованием радиохирургических методик. Дис. ... д-р мед. наук. М., 2001.

14. Urban J.A., Baker H.W. Radical mastectomy in continuity with en block resection of the internal mammary lymth chain. Cancer 1952;5:992–1008. 2

15. Lacour J., Lê M., Canceres E. et al. Radical mastectomy versus radical mastectomy plus internal mammary dissection ten-year results of an international co-operative trial in breast cancer. Cancer 1983;51:1941–3.

16. Meier P., Ferguson D.J., Karrison T. A controlled trial of extended radical versus radical mastectomy. Ten-year results. Cancer 1989;63:188–95.

17. Сигал Е.И., Хамидуллин Р.Г., Дружков Б.К. и др. Видеоторакоскопическая парастернальная лимфаденэктомия при раке молочной железы. В сб.: Материалы I съезда онкологов стран СНГ. М., 1996;с. 515–6.

18. Goldhirsch A., Ingle J.N., Gelber R.D. et al. Thresholds for therapies: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2009. Ann Oncol 2009;20(8):1319–29.


Review

For citations:


Uimanov V.A., Trigolosov A.V., Nechushkin M.I., Gladilina I.A. Comparative analysis of parasternal lymph collector exposures in the organ-sparing treatment of patients with operable breast cancer. Tumors of female reproductive system. 2010;(2):31-35. (In Russ.) https://doi.org/10.17650/1994-4098-2010-0-2-31-35

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ISSN 1994-4098 (Print)
ISSN 1999-8627 (Online)