Preview

Tumors of female reproductive system

Advanced search

Threat of fertility loss in cancer patients of reproductive age and the current feasibilities of ovarian tissue cryopreservation

https://doi.org/10.17650/1994-4098-2010-0-2-89-92

Abstract

To solve the problem of preserving reproductive function in cancer patients is very urgent today because antitumor treatment comprising different combinations of radio- and chemotherapy and surgery lead to ovarian reserve depletion and premature menopause in repro- ductive-aged women. The authors propose to consider one of the fertility preservation techniques – ovarian tissue cryopreservation. A procedure for cryopreservation is described in detail; its efficiency is evaluated. In the authors’ opinion, this procedure is one of most promising in preserving the sexual material of cancer patients.

About the Authors

A. A. Parokonnaya
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Science
Russian Federation


E. G. Tyrsina
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Science
Russian Federation


A. A. Lushnikova
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Science
Russian Federation


M. I. Nechushkin
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Science
Russian Federation


E. B. Kampova-Polevaya
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Science
Russian Federation


I. Yu. Davydova
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Science
Russian Federation


References

1. Manger K., Wildt L., Kalden J., Manger B. Prevention of gonadal toxicity and preservation of gonadal function and fertility in young women with systemic lupus erythematosus treated

2. by cyclophosphamide. Genomic and proteomic in Autoimmune Diagnostics 2006;5: 269–72.

3. Lower E.E., Blau R., Gazder P. et al. The risk of premature menopause induced by chemotherapy for early breast cancer. J Womens Health Gend Based Med 1999;8:949–54.

4. Meirow D., Schiff E. Appraisal of chemotherapy effects on reproductive outcome according to animal studies and clinical data. J Natl Cancer Inst Monographs 2005; (34): 21–5.

5. Oktay K., Reh A., Vahdat L. Measuring the impact of chemotherapy on fertility in women with breast cancer. JCO 2006;24:4044–6.

6. Meirow D., Baum M., Yaron R., Levron J., Hardan I., Schiff E., Nagler A., Yehuda D.B. Ovarian tissue cryopreservation in hematologic malignancy: ten years' experience. Leuk Lymphoma 2007;48 (8):1569–76.

7. Walshe J., Denduluri N., Swain S. Amenorrhea in Premenopausal Women After Adjuvant Chemotherapy. Breast Cancer J Clin Oncol 2006; 24:5769–79.

8. Lee S., Schover L., Partridge A. et al. American society of clinical oncology recommendations on fertility preservation in cancer patients. J Clin Oncol 2006;24(18):2917–31.

9. Левков Л. Криоконсервирование овариальной ткани человека: современное состояние. Тезисы докладов научно- практической конференции «Современные возможности вспомогательных репродуктивных технологий». СПб., 2006; с. 23 –24.

10. Donnez J., Dolmans M.M., Demylle D. et al. Livebirth after orthotopic transplantation of cryopreserved ovarian tissue. Lancet 2006;364:1405–10.

11. Oktay K., Economos K., Kan M. et al. Endocrine function and oocyte retrieval after autologous transplantation of ovarian cortical strips to the forearm. JAMA 2001;286:1490–3.

12. Oktay K., Karlikaya G. Ovarian function after transplantation of frozen, banked autologous ovarian tissue. N Engl J Med 2000;342: 1919.

13. Poirot C., Vacher-Lavenu M.C., Helardot P. et al. Human ovarian tissue cryopreservation: Indications and feasibility. Hum Reprod 2002;17:1447–52.

14. Radford J.A., Lieberman B.A., Brison D.R. et al. Orthotopic reimplantation of cryopreserved ovarian cortical strips after high-dose chemotherapy for Hodgkin’s lymphoma. Lancet 2001;357:1172–5.

15. Tryde Schmidt K.L., Yding Andersen C., Starup K. Orthotopic autotransplantation of cryopreserved ovarian tissue to a woman cured of cancer - follicular growth, steroid production and oocyte retrieval. Reprod Biomed Online 2004;8:448–53.


Review

For citations:


Parokonnaya A.A., Tyrsina E.G., Lushnikova A.A., Nechushkin M.I., Kampova-Polevaya E.B., Davydova I.Yu. Threat of fertility loss in cancer patients of reproductive age and the current feasibilities of ovarian tissue cryopreservation. Tumors of female reproductive system. 2010;(2):89-92. (In Russ.) https://doi.org/10.17650/1994-4098-2010-0-2-89-92

Views: 592


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1994-4098 (Print)
ISSN 1999-8627 (Online)