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Опухоли женской репродуктивной системы

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Роль ингибиторов сосудистого эндотелиального фактора роста в лечении рака яичников

https://doi.org/10.17650/1994-4098-2010-0-3-35-44

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Аннотация

Ангиогенез играет большую роль в развитии и метастазировании ряда опухолей, в особенности при опухолях женской репродуктивной системы. При раке яичников (РЯ) как в первичной опухоли, так и в метастазах и асцитической жидкости выявлен высокий уровень экспрессии сосудистого эндотелиального фактора роста (VEGF). Следовательно, использование препаратов, блокирующих VEGF, может оказаться эффективным при лечении РЯ. Наиболее изученным препаратом, применяющимся при лечении данной нозологии, является бевацизумаб, высокая эффективность которого подтверждена даже при использовании его в монотерапии у больных, получавших лечение многократно.

Об авторе

С. В. Хохлова
ГУ РОНЦ им. Н.Н. Блохина РАМН, Москва
Россия


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Для цитирования:


Хохлова С.В. Роль ингибиторов сосудистого эндотелиального фактора роста в лечении рака яичников. Опухоли женской репродуктивной системы. 2010;(3):35-44. https://doi.org/10.17650/1994-4098-2010-0-3-35-44

For citation:


Khokhlova S.V. Vascular endothelial growth factor inhibitors in the treatment of ovarian cancer. Tumors of female reproductive system. 2010;(3):35-44. (In Russ.) https://doi.org/10.17650/1994-4098-2010-0-3-35-44

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ISSN 1994-4098 (Print)
ISSN 1999-8627 (Online)