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Use of inhibin B in recurrent ovarian granulosa cell tumors

https://doi.org/10.17650/1994-4098-2010-0-3-68-72

Abstract

Early diagnosis of recurrent ovarian granulose cell tumors (OGCT) remains an urgent problem of modern oncogynecology. Inhibin B is one of the most potentially important markers of OGCT. Nevertheless, in the world there are today only single studies evaluating the clinical value of inhibin B. The paper presents serum inhibin B measurements in patients with recurrent OGCT. The findings suggest that inhibin B has a high (80-100%) diagnostic sensitivity and 100% specificity.

About the Authors

A. M. Beishembayev
Department of Oncology, Russian State Medical University, Russian Agency for Health Care
Russian Federation


N. V. Lyubimova
N.N. Blokhin Russian Cancer Research Cancer, Russian Academy of Medical Sciences, Moscow
Russian Federation


V. M. Abayev
N.N. Blokhin Russian Cancer Research Cancer, Russian Academy of Medical Sciences, Moscow
Russian Federation


K. I. Zhordania
N.N. Blokhin Russian Cancer Research Cancer, Russian Academy of Medical Sciences, Moscow
Russian Federation


V. A. Khailenko
Department of Oncology, Russian State Medical University, Russian Agency for Health Care
Russian Federation


References

1. Аксель Е.М., Давыдов М.И. и др. Статистика злокачественных опухолей яичников. М.: РОНЦ им. Н.Н. Блохина РАМН, 2009.

2. Карселадзе А.И. Морфология неэпителиальных опухолей яичников: Методические рекомендации. М.: МНИОИ им. П.А. Герцена, 1994.

3. Ranganath R. Clinical and pathologic prognostic factors in adult granulosa cell tumors of the ovary. Int J Gynecol Cancer 2008;18(5):929–33.

4. Robertson D.M., Cahir P., Burger H.G. et al. Inhibin forms in serum from postmenopausal women with ovarian cancer. Clin Endocrinol 1999;50:381–6.

5. Lee Y.K., Park N.H., Kim J.W. et al. Characteristics of recurrence in adult-type granulosa cell tumor. Int J Gynecol Cancer 2008;18(4):642–7.

6. Boggess J.F., Soules M.R., Goff B.A. et al. Serum inhibin and disease status in women with ovarian granulose cell tumors. Gynecol Оncol 1997;64:64–9.

7. Healy D.L., Burger H.G., Mamers P. et al. Elevated serum inhibin concentrations in postmenopausal women with ovarian tumors. N Engl J Med 1993;329:1539–1542.

8. Jobling T., Mamers P., Healy D.L. et al. A prospective study of inhibin in granulose cell tumors of the ovary. Gynecol Oncol 1994;55:285–9.

9. Lappohn R.E., Burger H.G., Bouma J. et al. Inhibin as a marker for granulose cell tumors. N Engl J Med 1989;321:790–3.

10. Robertson D.M., Cahir N., Burger H.G. et al. The development of a two-site immunofluorometric assay for serum inhibins and application to women with ovarian cancer. Proc 39th Ann Sci Meet Endocrin Soc. Australia, Sydney, 1996.

11. Mom C.H., Engelen M.J., Willemse P.H. et al. Granulosa cell tumors of the ovary: the clinical value of serum inhibin A and B levels in a large single center cohort. Gynecol Oncol 2007;105(2):365–72.


Review

For citations:


Beishembayev A.M., Lyubimova N.V., Abayev V.M., Zhordania K.I., Khailenko V.A. Use of inhibin B in recurrent ovarian granulosa cell tumors. Tumors of female reproductive system. 2010;(3):68-72. (In Russ.) https://doi.org/10.17650/1994-4098-2010-0-3-68-72

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ISSN 1994-4098 (Print)
ISSN 1999-8627 (Online)