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SPECIFIC FEATURE OF HORMONAL PROFILE IN PATIENTS WITH PRIMARY AND RECURRENT BREAST CANCER AND THEIR ROLE IN THE EFFICIENCY OF CHEMOTHERAPY

https://doi.org/10.17650/1994-4098-2009-0-1-2-29-33

Abstract

The hormonal background was studied in 32 menopausal patients who had primary breast cancer (Stage III) or its recurrence in the postoperative scar. The patients with the primary process, unlike those with a recurrence, were found to have increased adrenocortical cortisol-forming activity and changed thyroid homeostasis. In both types of the neoplastic process, the blood concentrations of estradi- ol, testosterone, prolactin, follicle-stimulating and luteinizing hormones were disturbed in a substantial number of cases; the distinc- tive feature of the primary process and its recurrence lies in the opposite direction. An association of individual differences in the con- centrations of estradiol and testosterone with the efficiency of neoadjuvant chemotherapy was analyzed in patients with recurrent can- cer.

About the Authors

M. B. Kozlova
Rostov Cancer Research Institute, Russian Agency for Medical Technologies
Russian Federation


E. M. Frantziyantz
Rostov Cancer Research Institute, Russian Agency for Medical Technologies
Russian Federation


G. A. Nerodo
Rostov Cancer Research Institute, Russian Agency for Medical Technologies
Russian Federation


R. N. Salatov
Rostov Cancer Research Institute, Russian Agency for Medical Technologies
Russian Federation


R. G. Luganskaya
Rostov Cancer Research Institute, Russian Agency for Medical Technologies
Russian Federation


I. P. Sidorenko
Rostov Cancer Research Institute, Russian Agency for Medical Technologies
Russian Federation


M. V. Kashubina
Rostov Cancer Research Institute, Russian Agency for Medical Technologies
Russian Federation


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Review

For citations:


Kozlova M.B., Frantziyantz E.M., Nerodo G.A., Salatov R.N., Luganskaya R.G., Sidorenko I.P., Kashubina M.V. SPECIFIC FEATURE OF HORMONAL PROFILE IN PATIENTS WITH PRIMARY AND RECURRENT BREAST CANCER AND THEIR ROLE IN THE EFFICIENCY OF CHEMOTHERAPY. Tumors of female reproductive system. 2009;(1-2):29-33. (In Russ.) https://doi.org/10.17650/1994-4098-2009-0-1-2-29-33

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ISSN 1994-4098 (Print)
ISSN 1999-8627 (Online)