No 1-2 (2009)

Supplementation of oral clodronate to postoperative adjuvant treatment for breast cancer (BC) considerably improves overall and relapse-free survival rates. The paper gives the results of a long-term follow-up of patients during a prospective randomized controlled study.
Subjects and methods. The study included patients with primary BC receiving clodronate in a dose of 1600 mg/day in combination with the conventional adjuvant therapy for BC.
Results. An analysis of 290 of 302 patients indicated a significant increase in overall survival in the clodronate group at a median fol- low-up of 103±12 months; during 8.5 years after primary surgical treatment, 20.4% and 40.7% of patients died in the clodronate and control groups, respectively (p = 0.04). The clodronate group did not show a considerable reduction in the rate of metastatic lesions in the bone and visceral organs or an increase in the relapse-free period following 36- and 55-month follow-ups.
Conclusions. The findings of better late overall survival rates confirm the results of earlier studies of oral clodronate in combination with the conventional adjuvant therapy for BC.

Organ-preserving surgical interventions can be performed owing to improved drug and radiation therapy methods. When radical resec- tion is contraindicated, radical mastectomy is carried out, which is a serious psychological trauma to a woman.
In this connection, plastic reparative surgery for breast malignancies is growing in importance. An operation using silicone implants is technically much simpler and less traumatic to patients; therefore one-stage repair with a Becker expanding endoprosthesis both alone and that in combination with displaced flaps occupy a highly important place.

The data given in the paper are based on the analysis of 121 women with breast cancer who were treated and followed up in the Tashkent City Cancer Dispensary in the period of 1999 to 2008. Long-term results were summarized in September 2008.

To increase tumor sensitivity to specific exposure, by minimizing damage to intact tissues is an urgent task in therapy for gynecological cancer at any site. Laser-induced hyperthermia (LIHT) is a very promising effective, safety, and cost-effective technique for modify- ing a tumor response for various modalities of multimodality treatment for gynecological cancer, including for the effective therapy for locally advanced tumors and recurrences which are resistant to traditional interventions.
The advantages of LIHT are firstly that it is able to regulate temperature and heating depth and volume in the real-time mode, by chang- ing the parameters of laser irradiation (wave length, power, exposure) from the data of direct thermometry used during a procedure.

The study has demonstrated that medical abortion in women with a history of breast cancer is not justified as a medical intervention in further pregnancy. After 2 years of the termination of treatment, there may be procreation in a patient with early cancer, a good prognosis, and an active wish to have a baby. At the same time, the patient should undergo a complete examination, involving a geneticist's counseling.