IMMUNITY IN PATIENTS WITH TROPHOBLASTIC DISEASE

B. O. Toloknov; Толокнов Б. О.; E. G. Slavina; Славина Е. Г.; Z. G. Kadagidze; Кадагидзе З. Г.; K. P. Laktionov; Лактионов К. П.; Е. Е. Makhova; Махова Е. Е.; A. I. Chertkova; Черткова А. И.; I. V. Markina; Маркина И. В.

doi:10.17650/1994-4098-2009-0-1-2-63-67

IMMUNITY IN PATIENTS WITH TROPHOBLASTIC DISEASE

Authors: Toloknov B.O.¹, Slavina E.G.¹, Kadagidze Z.G.¹, Laktionov K.P.¹, Makhova Е.Е.¹, Chertkova A.I.¹, Markina I.V.¹
Affiliations:
1. N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Issue: No 1-2 (2009)
Pages: 63-67
Section: GYNECOLOGY. PROBLEM
Published: 01.05.2009
URL: https://ojrs.abvpress.ru/ojrs/article/view/293
DOI: https://doi.org/10.17650/1994-4098-2009-0-1-2-63-67
ID: 293

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Abstract

The investigation included 39 female patients with different forms of trophoblastic disease whose immunity was studied by the cur- rently available procedures. The patients were divided into 2 groups. Group 1 comprised 29 patients with a history of hydatidiform mole, who received no chemotherapy (CT) since an analysis of the data did not show the presence of a trophoblastic tumor. Group 2 consisted of 10 patients with a verified trophoblastic tumor who received CT with various drugs. The patients with trophoblastic disease were found to have some abnormal immunological parameters; however, they differ little in patients with the malignant and benign course of the disease and cannot serve as a prognostic factor. Activated lymphocytes were substantially increased in both groups, suggesting an active immune response to antigen-foreign cells expressing along with parenteral antigens. The patients with hydatidiform mole have the sign to be further studied, that is a reduction in the count of СD25-positive Т lymphocytes, pos- sibly, suppressor cells.

Keywords

suppressor cells, trophoblastic disease, hydatidiform mole, chemotherapy, immunity

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IMMUNITY IN PATIENTS WITH TROPHOBLASTIC DISEASE

Full Text

Abstract

Keywords

About the authors

B. O. Toloknov

E. G. Slavina

Z. G. Kadagidze

K. P. Laktionov

Е. Е. Makhova

A. I. Chertkova

I. V. Markina

References

Supplementary files