Опухоли женской репродуктивной системы

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Роль COX-2 в регуляции метастатического потенциала опухолевых клеток молочной железы человека

Полный текст:


Проведен анализ экспрессии СOX-2, VEGF, VEGFR-1, VEGFR-2, VEGFR-3, EGFR, эндоглина (СD105), IL-6 в опухолевых клетках молочной железы человека с разным метастатическим потенциалом. Исследовалась роль данных факторов в регуляции мета- статического потенциала клеток рака молочной железы, а также роль СOX-2 в регуляции процессов метастазирования на клеточном уровне; оценивалась потенциальная способность опухолевых клеток молочной железы человека вырабатывать фак- торы, стимулирующие рост опухоли, ангиогенез и метастазирование.

Об авторах

М. А. Таипов
ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН, Москва

З. Н. Никифорова
ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН, Москва

И. А. Кудрявцев
ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН, Москва

Н. Е. Арноцкая
ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН, Москва

В. Е. Шевченко
ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН, Москва

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Для цитирования:

Таипов М.А., Никифорова З.Н., Кудрявцев И.А., Арноцкая Н.Е., Шевченко В.Е. Роль COX-2 в регуляции метастатического потенциала опухолевых клеток молочной железы человека. Опухоли женской репродуктивной системы. 2014;(1):8-14.

For citation:

Taipov M.A., Nikiforova Z.N., Kudryavtsev I.A., Arnotskaya N.Y., Shevchenko V.Y. Role of COX-2 in the regulation of the metastatic potential of human breast tumor cells. Tumors of female reproductive system. 2014;(1):8-14. (In Russ.)

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