Ultrasound diagnosis of iliac lymph node metastases in cancer of the cervix uteri
https://doi.org/10.17650/1994-4098-2014-0-4-57-67
Abstract
The Outpatient Ultrasound Diagnosis Group, Research Consulting Department, N. N. Blokhin Russian Cancer Research Center, studied the results of an examination in 93 patients with the verified diagnosis of cancer of the cervix uteri (CCU). To specify the extent of a tumor process, a comprehensive ultrasound examination was made in all the patients with verified CCU during their first visit. Our findings were statistically processed. According to our findings, ultrasound computed tomography is a highly informative method to diagnose retroperitoneal lymph node (LN) metastases, which defines the shape, sizes, structure, location, and number of metastatic LNs. Iliac LNs with reactive changes were detected in 24.7 % of CCU cases. No ultrasound signs of iliac LN metastatic involvement were found in 4.3 % of cases in the presence of CCU micrometastases. The number of metastatic regional LNs was validly proven to increase with larger tumor sizes. The threshold values of cervical
tumors were determined, which may presume the presence or absence of iliac LN metastases to have a rather high sensitivity and specificity. The risk of LN metastatic involvement was validly proven to be 4.1-fold higher with greater two or more threshold values of a cervical tumor.
About the Authors
Ye. V. Barinova
N. N. Blokhin Russian Cancer Research Center, Moscow
Russian Federation
Russian Federation
M. A. Chekalova
N. N. Blokhin Russian Cancer Research Center, Moscow
Russian Federation
Russian Federation
Ye. K. Dvorova
N. N. Blokhin Russian Cancer Research Center, Moscow
Russian Federation
Russian Federation
References
1. Лекции по онкогинекологии. Под ред. М.И. Давыдова, В.В. Кузнецова, В.М. Нечушкиной. М.: МЕДпресс-информ, 2009. С. 199–225.
2. Аксель Е.М. Статистика злокачественных новообразований женской половой сферы. Онкогинекология 2012;1:18–23.
3. Наука практическому врачу. Лекции по онкогинекологии. Под ред. В.В. Кузнецова, В.А. Хайленко. М.: ООО «ЛЮКС ПРИНТ», 2009. С. 33–6.
4. Важенин А.В., Жаров А.В., Шимоткин И.Г. Актуальные вопросы клинической онкологии. М.: ООО Фирма «СТРОМ», 2010. С. 6–33.
5. Морхов К.Ю., Кузнецов В.В., Лебедев А.И. и др. Современные подходы к лечению рака шейки матки. Онкогинекология 2005;1:16–20.
6. Бохман Я.В. Руководство по онкогинекологии. СПб.: ООО «Издательство Фолиант», 2002. С. 195–229.
7. Гончарук И.В., Воробьева Л.И., Неспрядько С.В., Пузырная И.Н. Ретроспективный анализ больных с рецидивами и метастазами рака шейки матки. Сборник материалов VII Съезда онкологов России. М., 2009. Т. 2.
8. Калабанова Е.А. Особенности клинического течения и прогноза метастазов рака шейки матки. Дис. ... канд. мед. наук. Ростов-на-Дону, 2011.
9. Inoue Т., Morita K. The prognostic significance of number of positive nodes in cervical carcinoma stages IB, IIA and IIB. Cancer 1990;65(9):1923–7.
10. Nogushi Н., Shiozawa I., Sakai Y. et al. Pelvic lymph node metastasi of uterine cervical cancer. Gynecol Oncol 1987;27(2):150–8.
11. Kodama J., Seki N., Ojima Y. et al. Prognostic factors in node-positive patients with stage IB-IIB cervical cancer treated by radical hysterectomy and pelvic lymphadenectomy. J Gynaecol Obstet 2006;93(2):130–5.
12. Matsuura Y., Kawagoe T., Toki N. et al. Long-standing complications after treatment for cancer of the uterine cervix—clinical significance of medical examination at 5 years after treatment. Int J Gynecol Cancer 2006;16(1):294–7.
13. Дигай Л.К., Шаназаров Н.А. Васьковская О.В., Асабаева Р.И. Сравнительный анализ методов УЗИ и МРТ исследования в первичной диагностике рака шейки матки. Совр пробл науки и обр 2013;1.
14. Choi H.J., Roh J.W., Seo S.S. et al. Comparison of the accuracy of magnetic resonance imaging and positron emission tomography computed tomography in the presurgical detection of lymph node metastases in patients with uterine cervical carcinoma: a prospective study. Cancer 2006;106(4): 914–22.
15. Park W., Park Y.J., Huh S.J. et al. The usefulness of MRI and PET imaging for the detection of parametrial involvement and lymph node metastasis in patients with cervical cancer. Jpn J Clin Oncol 2005;35(5):260–4.
16. Rockall A.G., Sohaib S.A., Harisinghani M.G. et al. Diagnostic performance of nanoparticle-enhanced magnetic resonance imaging in the diagnosis of lymph node metastases in patients with endometrial and cervical cancer. J Clin Oncol 2005;23(12):2813–21.
17. Хоружик С.А., Косенко И.А., Матылевич О.П. и др. Возможности магнитно-резонансной томографии в стадировании рака шейки матки и оценке эффективности неоадъювантной химиотерапии. Онкологический журнал 2010;4(1): 54–60.
Review
For citations:
Barinova Ye.V., Chekalova M.A., Dvorova Ye.K. Ultrasound diagnosis of iliac lymph node metastases in cancer of the cervix uteri. Tumors of female reproductive system. 2014;(4):57-67. (In Russ.) https://doi.org/10.17650/1994-4098-2014-0-4-57-67
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