Cerebral metastases of endometrial carcinoma. Diagnostic and neurosurgical aspects
https://doi.org/10.17650/1994-4098-2013-0-1-2-72-82
Abstract
Central nervous system (CNS) involvement by endometrial carcinoma is uncommon. Among 1710 patients registered for brain metastases at our institution between 1990 and 2012, 3 (0.18 %) developed brain metastases. All lesions (1 multiple, 2 single) were contrast enhancing on com- puted tomography scans, and were located in the cerebrum (lobus occipitalis) in 2 cases. The CNS was the only site of detectable disease in 1 patient with recurrent disease. One patient received radiotherapy (survival, 3 months) and two underwent surgical resection of solitary metas- tasis followed by radiotherapy (survival = 3 and 5 months and alive to the present). Prognosis of patients with CNS metastases from endometrial carcinoma appears poor; however, in a selected group of patients early diagnosis followed by multimodal treatment may result in a palliation of the disease.
About the Authors
N. V. Sevyan
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Russian Federation
Russian Federation
V. B. Karakhan
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Russian Federation
Russian Federation
Yu. A. Tsybulskaya
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Russian Federation
Russian Federation
Yu. V. Bondarenko
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Russian Federation
Russian Federation
References
1. Ruelle A., Zuccarello M., Andrioli G. Brain metastasis from endometrial carcinoma. Report of two cases. Neurosurg Rev 1994;17(1):83–7.
2. Gavrilovic I.T., Posner J.B. Brain metastasis: epidemiology and pathophysiology. J Neurooncol 2005;75(1):5–14.
3. Kottke-Marchant K., Estes M.L., Nunez C. Early brain metastases in endometrial carcinoma. Gynecol Oncol 1991;41(1):67–73.
4. Forster M.D., Dedes K.J., Sandhu S. et al. Treatment with olaparib in a patient with PTEN-deficient endometrioid endometrial cancer. Nat Rev Clin Oncol 2011;8(5):302–6.
5. Savage J., Subby W., Okagaki T. Adenocarcinoma of the endometrium with trophoblastic differentiation and metastases as choriocarcinoma: a case report. Gynecol Oncol 1987;26(2):257–62.
6. Корниенко В.Н., Пронин И.Н., Фадеева Л.М., Долгушин М.Б. Метод КТ- перфузии в дифференциальной диагностике вторичного опухолевого поражения голов- ного мозга. Мед визуализация 2007;4:100–6.
7. Карахан В.Б., Фу Р.Г., Алешин В.А. и др. Новые хирургические технологии удале- ния метастазов рака в головном мозге в за- висимости от топографии, количества и макроструктуры опухолевых узлов. В кн.: Современные проблемы нейроонкологии. М.: Изд-во РОНЦ им. Н.Н. Блохина РАМН, 2007. С. 6–12.
8. Aalders J.G., Abeler V., Kolstad P. Recurrent adenocarcinoma of the endometrium: a clinical and histopathological study of 379 patients. Gynecol Oncol 1984;17(1):85–103.
9. Brezinka C., Fend F., Huter O., Plattner A. Cerebral metastasis of endometrial carcinoma. Gynecol Oncol 1990;38(2):278–81.
10. Chura J.C., Marushin R., Boyd A. et al. Multimodal therapy improves survival in patients with CNS metastasis from uterine cancer: a retrospective analysis and literature review. Gynecol Oncol 2007;107(1):79–85.
11. Cormio G., Lissoni A., Losa G. et al. Brain metastases from endometrial carcinoma Gynecol Oncol 1996;61(1):40–3.
12. Crispino M., Tira A., Volpi D., Olivetti L. Solitary cerebral metastasis of endometrial carcinoma. Radiol Med 2000;100(6):515–7.
13. De Porre P.M., Subandono Tjokrowardojo A.J. Brain metastases of endometrial carcinoma. Case report and review of literature. Strahlenther Onkol 1992;168(2):100–1.
14. Gien L.T., Kwon J.S., D’Souza D.P. et al. Brain metastases from endometrial carcinoma: a retrospective study. Gynecol Oncol 2004;93(2):524–8.
15. Le Chevalier T., Smith F.P., Caille P. et al. Sites of primary malignancies in patients presenting with cerebral metastases: a review of 120 cases. Cancer 1985;56(4):880–2.
16. Lee W.J., Chen C.H., Chow S.N. Brain metastases from early stage endometrial carcinoma 8 years after primary treatment: case report and review of the literature. Acta Obstet Gynecol Scand 2006;85(7):890–1.
17. Llaneza-Coto A.P., Seco-Navedo M., Fernández-García T., Redondo-Onia M. Brain metastases of endometrial carcinoma in a young woman. Prog Obstet Ginecol 2006;49(2):82–4.
18. Mahmoud-Ahmed A.S., Suh J.H., Barnett G.H. et al. The effect of radiation therapy on brain metastases from endometrial carcinoma: a retrospective study Gynecol Oncol 2001;83(2):305–9.
19. Savage J., Subby W., Okagaki T. Adenocarcinoma of the endometrium with trophoblastic differentiation and metastases as choriocarcinoma: a case report. Gynecol Oncol 1987;26(2):257–62.
20. Sawaya R. Bindal Metastatic brain tumors. Brain tumors. An Encyclopedic Approach. Eds.: A.H. Kaye, E.R. Laws. Edinburg: Churchill Livingstone, 1995. Pp. 923–46.
21. Jemal A., Siegel R., Xu J., Ward E. Cancer statistics, 2010. CA Cancer J Clin 2010;60(5):277–300.
22. Martínez-Mañas R.M., Brell M., Rumià J., Ferrer E. Brain metastases in endometrial carcinoma Gynecol Oncol 1998;70(2):282–4.
23. National Cancer Institute. Surveillance Epidemiology and End Results [SEER]. http:// seer.cancer.gov/csr/1975_2007/browse_csr.php.
24. CancerStats – Cancer Statistics for the UK: Cancer Research UK. Updated 3 November 2011. http://info.cancerresearchuk. org/cancerstats.
25. Ferlay J., Shin H.R., Bray F. et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010;127(12):2893–917.
26. Bristow R.E., Santillan A., Zahurak M.L. et al. Salvage cytoreductive surgery for recurrent endometrial cancer. Gynecol Oncol 2006;103(1):281–7.
27. Berge T., Lundberg S. Cancer in Malmö 1958–1969. An autopsy study. Acta Pathol Microbiol Scand Suppl 1977;(260):1–235.
28. Graf A.H., Buchberger W., Langmayr H., Schmid K.W. Site preference of metastatic tumours of the brain. Virchows Arch A Pathol Anat Histopathol 1988;412(5):493–8.
29. Ogawa K., Toita T., Kakinohana Y. et al. Palliative radiation therapy for brain metastases from endometrial carcinoma: report of two cases. Jpn J Clin Oncol 1999;29(10):498–503.
30. Orrù S., Lay G., Dessì M. et al. Brain metastases from endometrial carcinoma: report of three cases and review of the literature. Tumori 2007;93(1):112–17.
Review
For citations:
Sevyan N.V., Karakhan V.B., Tsybulskaya Yu.A., Bondarenko Yu.V. Cerebral metastases of endometrial carcinoma. Diagnostic and neurosurgical aspects. Tumors of female reproductive system. 2013;(1-2):72-82. (In Russ.) https://doi.org/10.17650/1994-4098-2013-0-1-2-72-82
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