An integrated approach to the diagnosis and evaluation of uterine myoma in growth rates

The incidence of uterine myoma, including rapid-growing, in a population is sufficiently high and does not tend to decrease. Therefore, assessment of growth of uterine myoma is important for the early selection of adequate tactics of these patients. At the same time, there are no clear criteria for the practitioner to decide on the optimal amount of treatment. One approach to solving this problem is the development of new methods of diagnosis of clinical and morphological variants of uterine myoma. In this regard, we studied and compared features of the structures of solids menstrual content of markers of proliferation and apoptosis (APRIL and TRAIL) in patients with slow- (simple) and rapid-growing uterine myoma. The relationship between the clinical and morphological parameters, the rate of growth of uterine myoma, the levels of APRIL and TRAIL, and abnormal structures identified in menstrual secretions of patients using the method of boundary dehydration. The study included 111 women aged 31 to 56 years. They were divided into three groups: control, which included 41 patients without gynecological diseases; the second one, which included 40 patients with slow-growing and the third one – 30 patients with rapid-growing uterine myoma. Objective: to develop a combined approach to the diagnosis of rapid-growing uterine myoma by determining structural features of the biological fluid – menstrual flow, identifying them ligand induces proliferation (APRIL), and the ligand induces apoptosis (TRAIL). The study used сlinical, biochemical, statistical methods and the method boundary dehydration of biological fluids.