Optimization of a diagnostic algorithm for benign breast nodules
https://doi.org/10.17650/1994-4098-2016-12-1-32-36
Abstract
The results of examinations were studied in 76 reproductive-aged patients with benign breast nodules (BBNs). The determination of the leukocyte common antigen CD45 in the trephine biopsy specimens, as well as proteinase activity in the solid tumor homogenates and in the cyst puncture samples in the preoperative stage or the postpuncture period can identify groups of patients with BBNs in relation to a tissue inflammatory response. BBNs with a tissue inflammatory response showed increases in the level of nonspecific proteinases and in the expression of the leukocyte common antigen CD45, which was accompanied enhanced proliferative activity (Ki-67) and elevated levels of apoptosis proteins (p53 and Bcl-2), and estrogen and prolactin receptors.
About the Authors
T. E. Usmanova
S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University; 5/7 Lenina Boulevard, Simferopol, 295006, Russia
Russian Federation
Russian Federation
F. N. Il’chenko
S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University; 5/7 Lenina Boulevard, Simferopol, 295006, Russia
Russian Federation
Russian Federation
A. S. Filatov
S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University; 5/7 Lenina Boulevard, Simferopol, 295006, Russia
Russian Federation
Russian Federation
A. V. Kubyshkin
S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University; 5/7 Lenina Boulevard, Simferopol, 295006, Russia
Russian Federation
Russian Federation
References
1. Лукавенко И.М., Андрющенко В.В., Кононенко Н.Г. и др. Клиническое значение экспрессии рецепторов эстрогена, прогестерона и маммаглобина при предопухолевой патологии молочных желез в практике хирурга-маммолога. Журнал клінічних та експериментальних медичних досліджень 2013;1(1):100–5. [Lukavenkо I.М., Аndryushchenko V.V., Kononenkо N.G. et al. Clinical value of the expression of estrogen, progesterone and mammaglobine receptors at the pre-tumor pathology of mammary glands in the practice of the mammologist surgeon. Zhurnal klinichnikh ta eksperimental’nikh medichnikh doslidzhen’ = Journal of Clinical and Experimental Medical Research 2013;1(1):100–5. (In Ukr.)].
2. Андрющенко В.В., Леонов В.В., Язиков О.В. и др. Онкопластичні операціі в лікуванні хворих на полікістоз молочних залоз. Харкiвська хiрургiчна школа 2012;3(54):39–42. [Аndushchenkо V.V., Leonov V.V., Yazikov О.V. et al. Оncoplastic operations in the treatment of patients with the cystic disease of mammary glands. Khar’kivska khirurgichna shkola = Kharkiv Surgical School 2012;3(54):39–42. (In Ukr.)].
3. Зорин Е.А. Малоинвазивные вмешательства при доброкачественных узловых образованиях молочной железы. Дис. ... канд. мед. наук. М., 2008. 110 c. [Zorin Е.А. Мinimally invasive interferences at benign palpable abnormalities of the mammary gland. Thesis … of candidate of medicine. Мoscow, 2008. 110 p. (In Russ.)].
4. Масленникова А.В., Голубятников Г.Ю., Орлова А.Г. и др. Неинвазивный оптический метод оценки кислородного статуса новообразований молочной железы. Опухоли женской репродуктивной системы 2010;(1):5–10. [Маslennikova А.V., Golubyatnikov G.Yu., Оrlovа А.G. et al. Noninvasive optical method of the evaluation of the oxygen status of mammary gland tumors. Opukholi zhenskoy reproduktivnoy sistemy = Tumors of the Female Reproductive System 2010;(1):5–10. (In Russ.)].
5. Дубініна В.Г., Четверіков С.Г., Заволока О.В. та ін. Оптимізація алгоритму діагностики доброякісних вузлових новоутворень молочних залоз. Хірургія України 2013;(4):88–91. [Dubininа V.G., Chetverikov S.G., Zavoloka О.V. et al. Оptimization of the algorithm of diagnostics of benign nodular tumors of mammary glands. Khirurgiya Ukraini = Surgery of Ukraine 2013;(4):88–91. (In Ukr.)].
6. Sangma M.B., Panda К., Dasiah S. A clinico-pathological study on benign brest diseases. J Clin Diagn Res 2013;7(3):503–6.
7. Zavoloka A.V. Benign breast tumors diagnosis: recent advances. J Health Sci 2013;3(10):665–74.
8. Овсянникова Т.В. Возможности терапии дисгормональной патологии молочных желез у женщин с гинекологическими заболеваниями. Акушерство, гинекология и репродукция 2010;4(2):28–32. [Оvsyannikovа Т.V. Possibilities for the therapy of dishormonal pathologies of mammary glands at women with gynecologic diseases. Akusherstvo, ginekologiya i reproduktsiya = Obstetrics, Gynecology and Reproduction 2010;4(2):28–32. (In Russ.)].
9. Тагиева Т.Т. Доброкачественные узловые образования молочных желез у женщин репродуктивного возраста. Вестник РОНЦ им. Н.Н. Блохина РАМН 2007;18(4):54–9. [Таgievа Т.Т. Benign nodular tumors of mammary glands at women of reproductive age. Vestnik RONC im. N.N. Blokhina RAMN = Herald of N.N. Blokhin RCRC of RAMS 2007;18(4):54–9. (In Russ.)].
10. Боженко В.К., Кудинова Е.А., Мельникова Н.В. и др. Анализ пролиферативной активности и апоптоза при гиперпластических процессах молочной железы. Вестник РНЦPР 2010;10. [Bozhenko V.K., Kudinovа Е.А., Меl’nikova N.V. et al. Аnalysis of the proliferative activity and apoptosis at hyperplastic processes of the mammary gland. Vestnik RNCRR = Herald of RNCCR2010;10. (In Russ.)].
11. Yu H., Kortylewski М., Pardoll D. Crosstalk between cancer and immune cells: role of STAT3 in the tumor microenvironment. Nat Rev Immunol 2007;7(1):41–51.
12. Mantovani A., Allavena Р., Sica А., Balkwill F. Cancer-related inflammation. Nature 2008;454(7203):436–44.
13. Grivennikov S.I., Karin M. Inflammation and oncogenesis: a vicious connection. Сurr Opin Genet Dev 2010;20(1):65–71.
14. Шайкина А.С., Рыжавский Б.Я., Беков С.В. Иммуногистохимический анализ рецепторов эстрогенов и прогестерона, Ki-67 в молочной железе в норме, при раке и доброкачественных опухолях. Дальневосточный медицинский журнал 2011;(1): 34–7. [Shaykinа А.S., Ryzhavskiy B.Ya., Bekov S.V. Immune histochemical analysis of estrogens and progesterone, Ki-67 in the mammary gland in health, at cancer and at benign tumors. Dal’nevostochnyy meditsinskiy zhurnal = Far Eastern Medical Journal 2011;(1):34–7. (In Russ.)].
15. Березов Т.Т., Чернов Н.Н., Штиль А.А. и др. Матриксные протеиназы и их тканевые ингибиторы при раке молочной железы. Вопросы биологической, медицинской и фармацевтической химии 2011;(12):37–44. [Berezov Т.Т., Chernov N.N., Shtil’ А.А. et al. Маtrix proteinase and its tissue inhibitors at the mammary gland cancer. Voprosy biologicheskoy, meditsinskoy i farmatsevticheskoy khimii = Issues of the Biologic, Medical and Pharmaceutical Chemistry 2011;(12):37–44. (In Russ.)].
16. Eiseler Т., Döppler H., Yan I.K. et al. Protein kinase D1 regulates matrix metallo proteinase expression and inhibits breast cancer cell invasion. Breast Cancer Res 2009; 11(1):R13.
Review
For citations:
Usmanova T.E., Il’chenko F.N., Filatov A.S., Kubyshkin A.V. Optimization of a diagnostic algorithm for benign breast nodules. Tumors of female reproductive system. 2016;12(1):32-36. (In Russ.) https://doi.org/10.17650/1994-4098-2016-12-1-32-36
Views:
793
Email this article 