Роль каскада циклооксигеназы-2 в метастазировании рака молочной железы

Современные подходы в терапии, основанные на изучении генетического портрета опухоли, все сильнее индивидуализируют ле- чебную тактику, что создает реальные перспективы выздоровления все большего числа пациенток. Экспериментальные и кли- нические данные показали, что повышенная экспрессия гена СОХ-2 увеличивает риск метастазирования рака молочной железы (РМЖ) в отдаленные органы. В ряде исследований последних лет обнаружено, что селективные ингибиторы фермента СОХ-2 способны тормозить пролиферацию, индуцировать апоптоз клеток РМЖ и угнетать неоангиогенез в опухоли. Однако в этой области много неясных и спорных вопросов, экспериментальное решение которых еще впереди. Наш обзор посвящен теоретическим предпосылкам и анализу результатов исследований роли COX-2 в метастазировании РМЖ.

рак молочной железы, СOX-2, СOX-1, простагландины, PGE2, сигнальный путь, маркеры метастазирования, мишени для таргетной терапии

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