Роль каскада циклооксигеназы-2 в метастазировании рака молочной железы
Аннотация
Современные подходы в терапии, основанные на изучении генетического портрета опухоли, все сильнее индивидуализируют ле- чебную тактику, что создает реальные перспективы выздоровления все большего числа пациенток. Экспериментальные и кли- нические данные показали, что повышенная экспрессия гена СОХ-2 увеличивает риск метастазирования рака молочной железы (РМЖ) в отдаленные органы. В ряде исследований последних лет обнаружено, что селективные ингибиторы фермента СОХ-2 способны тормозить пролиферацию, индуцировать апоптоз клеток РМЖ и угнетать неоангиогенез в опухоли. Однако в этой области много неясных и спорных вопросов, экспериментальное решение которых еще впереди. Наш обзор посвящен теоретическим предпосылкам и анализу результатов исследований роли COX-2 в метастазировании РМЖ.
Ключевые слова
рак молочной железы,
СOX-2,
СOX-1,
простагландины,
PGE2,
сигнальный путь,
маркеры метастазирования,
мишени для таргетной терапии
Об авторах
М. А. Таипов
ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва
Россия
Россия
И. А. Кудрявцев
ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва
Россия
Россия
К. П. Лактионов
ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва
Россия
Россия
Н. Е. Левченко
ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва
Россия
Россия
В. Е. Шевченко
ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва
Россия
Россия
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Для цитирования:
Таипов М.А., Кудрявцев И.А., Лактионов К.П., Левченко Н.Е., Шевченко В.Е. Роль каскада циклооксигеназы-2 в метастазировании рака молочной железы. Опухоли женской репродуктивной системы. 2013;(3-4):12-17. https://doi.org/10.17650/1994-4098-2013-0-3-4-12-17
For citation:
Taipov M.A., Kudryavtsev I.A., Laktionov K.P., Levchenko N.E., Shevchenko V.E. Role of a cyclooxygenase-2 cascade in breast cancer cell dissemination. Tumors of female reproductive system. 2013;(3-4):12-17. (In Russ.) https://doi.org/10.17650/1994-4098-2013-0-3-4-12-17
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