PREDICTION OF METASTATIC DAMAGE OF REGIONAL LYMPHATIC NODES IN PATIENTS WITH BREAST CANCER
https://doi.org/10.17650/1994-4098-2017-13-2-13-19
Abstract
Purpose of the study. Solving the problem of searching for prognostic factors of metastatic lesion of regional lymph nodes among the morphological and molecular characteristics of the primary breast tumor will bring modern oncology closer to finding the optimal model for individualizing diagnosis and treatment of breast cancer.
Materials and methods. The statistical analysis of clinical data and morphological factors obtained in the oncology department of the breast pathology of the Voronezh regional clinical oncological dispensary during a comprehensive study involving 223 patients was carried out. Only the stages I T1N0M0 and IIa T2N0M0 were taken into account.
Results and discussion. The study found that patients with a lack of metastases are characterized by a relatively smaller average tumor size (20.43 ± 9.28 mm) than in patients with metastases (27.43 ± 12.4 mm), with 25 % of them having Size ≤10 mm, 50 % – from 10 to 34 mm and 25 % – ≥ 34 mm. The difference in groups on the basis of “age” is absent. A statistical relationship (p < 0.05) between the biological tumor subtype and its histological diagnosis, between the biological tumor subtype and histological diagnosis and the absence / presence of metastases in the lymph nodes (p <0.0001) was established.
Conclusions. Thus, it was established that the histological and morphological study of the primary tumor provides the necessary information not only to determine its sensitivity to different types of systemic treatment and the choice of therapeutic tactics, but also to solve the problem of predicting the metastatic lesion of regional lymph nodes in breast cancer patients.
About the Authors
A. Kh. Ismagilov
Kazan State Medical Academy, Ministry of Health of Russia
Russian Federation
Russian Federation
36 Butlerov Str., Kazan, 420012, Republic of Tatarstan
N. G. Asnina
Voronezh state University of Ministry of Education and Science of Russia
Russian Federation
Russian Federation
1 University Square, Voronezh, 394018
I. P. Moshurov
Voronezh Regional Clinical Oncology Dispensary
Russian Federation
Russian Federation
4 Vaitsekhovskiy Str., Voronezh, 394036
G. A. Azarov
Voronezh Regional Clinical Oncology Dispensary
Russian Federation
Russian Federation
4 Vaitsekhovskiy Str., Voronezh, 394036
References
1. Семиглазов В.Ф. Новые подходы к лечению рака молочной железы. Вопросы онкологии 2013;3:288–291. [Semiglazov V.F. New approaches to the treatment of breast cancer. Voprosy onkologii = Problems in Oncology 2013;3: 288–291. (In Russ.)].
2. Канаев С.В., Новиков С.Н., Семиглазов В.Ф. и др. Радионуклидная визуализация путей лимфооттока от опухолей молочной железы. Вопросы онкологии 2010;4: 417–423. [Kanaev S.V., Novikov S.N., Semiglazov V.F. et al. Radionuclide imaging of the lymphatic drainage pathways from breast tumors. Voprosy onkologii = Problems in Oncology 2010;4:417–423. (In Russ.)].
3. Чернов В.И., Афанасьев С.Г., Синилкин И.Г. и др. Радионуклидные методы исследования в выявлении «сторожевых» лимфатических узлов. Сибирский онкологический журнал 2008;4:5–10. [Chernov V.I., Afanasyev S.G., Sinilkin I.G. et al. Radionuclide methods for the detection of sentinel lymph nodes. Sibirskiy onkologicheskiy zhurnal = Siberian Journal of Oncology 2008;4:5–10. (In Russ.)].
4. Lyman G.H., Giuliano A.E., Somerfield M.R. et al. American society of clinical oncology guideline recommendations for sentinel lymph node biopsy in earlystage breast cancer. J Clin Oncol 2005; 23:7703–7720. DOI: 10.1200/JCO.2005.08.001. PMID: 16157938.
5. Nieweg O.E., Rijk M.C., Olmos R.A.V., Hoefnagel C.A. Sentinel node biopsy and selective lymph node clearance – impact on regional control and survival in breast cancer and melanoma. J Nucl Med 2005;32:631-634. DOI: 10.1007/s00259-005-1801-4. PMID: 15875179.
6. Криворотько П.В., Дашян Г.А., Палтуев Р.М., Зернов К.Ю., Бессонов А.А. и др. Биопсия сигнальных лимфатических узлов при раке молочной железы. Злокачественные опухоли 2016;4(спецвып.1):4–8. [Krivorotko P.V., Dashyan G.A., Paltuev R.M., Zernov K. Yu., Bessonov A.A. et al. Sentinel lymph node biopsy in breast cancer. Zlokachestvennye opukholi = Malignant tumors 2016;4(special issue No. 1):4–8. (In Russ.)].
7. Giuliano A.E., Hunt K.K., Ballman K.V. et al. Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis. A Randomized clinical trial. JAMA 2011;305(6):569–575. DOI: 10.1001/jama.2011.90.l PMID: 21304082.
8. Семиглазов В.Ф., Канаев С.В., Пожарисский К.М. и др. Стратегия лечения рака молочной железы, основанная на выделении биологических подтипов. Врач 2011;12:28–34. [Semiglazov V.F., Kanaev S.V., Pozharisskiy K.M.et al. Treatment strategy for breast cancer based on the identification of its biological subtypes. Vrach = Physician 2011;12:28–34. (In Russ.)].
9. Семиглазов В.Ф. Планирование лечения рака молочной железы в зависимости от биологического подтипа. Вопросы онкологии 2014;60(4):529–530. [Semiglazov V.F. Choosing a treatment strategy for breast cancer depending on its biological subtype. Voprosy onkologii = Problems in Oncology 2014;60(4):529–530. (In Russ.)].
10. Кремер Н.Ш. Теория вероятностей и математическая статистика. М.: ЮНИТИ-ДАНА, 2004. [Kremer N.Sh. Probability theory and mathematical statistics. Moscow: UNITY-DANA, 2004. (In Russ.)].
11. Боровиков В. Statistica. Искусство анализа данных на компьютере: для профессионалов. Питер, 2003. [Borovikov V. Statistica. Data analysis using computer: for professionals. Saint Petersburg, 2003. (In Russ.)].
Review
For citations:
Ismagilov A.Kh., Asnina N.G., Moshurov I.P., Azarov G.A. PREDICTION OF METASTATIC DAMAGE OF REGIONAL LYMPHATIC NODES IN PATIENTS WITH BREAST CANCER. Tumors of female reproductive system. 2017;13(2):13-19. (In Russ.) https://doi.org/10.17650/1994-4098-2017-13-2-13-19
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