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Опухоли женской репродуктивной системы

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ДИАГНОСТИКА И ПРОФИЛАКТИКА КАРДИОТОКСИЧНОСТИ У БОЛЬНЫХ РАКОМ МОЛОЧНОЙ ЖЕЛЕЗЫ С ПОЗИЦИЙ ОНКОЛОГА И КАРДИОЛОГА

https://doi.org/10.17650/1994-4098-2017-13-3-17-27

Аннотация

Знание патогенеза и основных факторов риска кардиотоксичности антрациклиновыми антибиотиками (АА) позволило разработать различные методики, направленные на предупреждение и раннее выявление кардиотоксичности, а также создать ряд рекомендаций по уменьшению риска ее развития. Традиционные АА являются важнейшей опцией лечения метастатического рака молочной железы, включая повторное их назначение. Однако возможности их применения значительно ограничены из-за различных проявлений токсичности, особенно кумулятивной кардиотоксичности. Наиболее перспективным является применение пегилированных липосомных лекарственных форм АА. И в их ряду пегилированный липосомальный доксорубицин благодаря своей уникальной формуле практически не обладает антрациклиновой кардиотоксичностью, так как накапливается преимущественно в опухолевой ткани.

Об авторах

Т. Ю. Семиглазова
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Петрова» Минздрава России; ФГБОУ ВО «Cеверо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России
Россия

Татьяна Юрьевна Семиглазова.

197758, Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68; 191015, Санкт-Петербург, ул. Кирочная, 41



Г. М. Телетаева
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Петрова» Минздрава России
Россия

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68



Н. А. Козявин
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Петрова» Минздрава России
Россия

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68



А. В. Загатина
ООО «Клиника “Медика”»
Россия

191144, Санкт-Петербург, ул. Дегтярная, 23/25 лит. А, помещение 8Н



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Рецензия

Для цитирования:


Семиглазова Т.Ю., Телетаева Г.М., Козявин Н.А., Загатина А.В. ДИАГНОСТИКА И ПРОФИЛАКТИКА КАРДИОТОКСИЧНОСТИ У БОЛЬНЫХ РАКОМ МОЛОЧНОЙ ЖЕЛЕЗЫ С ПОЗИЦИЙ ОНКОЛОГА И КАРДИОЛОГА. Опухоли женской репродуктивной системы. 2017;13(3):17-27. https://doi.org/10.17650/1994-4098-2017-13-3-17-27

For citation:


Semiglazova T.Yu., Teletaeva G.M., Kozyavin N.A., Zagatina A.V. DIAGNOSIS AND PREVENTION OF CARDIOTOXICITY IN PATIENTS WITH BREAST CANCER FROM THE STANDPOINT OF AN ONCOLOGIST AND A CARDIOLOGIST. Tumors of female reproductive system. 2017;13(3):17-27. (In Russ.) https://doi.org/10.17650/1994-4098-2017-13-3-17-27

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ISSN 1994-4098 (Print)
ISSN 1999-8627 (Online)