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RESULTS OF EARLY-STAGE BREAST CANCER PATIENTS’ TREATMENT USING ACCELERATED PARTIAL BREAST IRRADIATION TECHNIQUE AFTER BREAST-CONSERVING SURGERY. EXPERIENCE OF N.N. BLOKHIN NATIONAL MEDICAL RESEARCH CENTER OF ONCOLOGY
- Authors: Trofimova O.P.1,2, Volkova N.V.1, Nazarenko A.V.1, Kolyadina I.V.2, Haylenko V.A.1, Tkachev S.I.1, Pryamikova J.I.1, Timoshkina E.V.1, Zaychenko O.S.1, Boldyreva V.A.1, Vorotnikov I.K.1, Alieva S.B.1, Borisova T.N.1, Glebovskaya V.V.1, Ivanov S.M.1
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Affiliations:
- N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
- Russian Medical Academy of Continuous Professional Education at the Ministry of Health of Russia
- Issue: Vol 13, No 4 (2017)
- Pages: 10-18
- Section: MAMMOLOGY. ORIGINAL REPORTS
- Published: 22.12.2017
- URL: https://ojrs.abvpress.ru/ojrs/article/view/557
- DOI: https://doi.org/10.17650/1994-4098-2017-13-4-10-18
- ID: 557
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Abstract
Objective: to analyze the results of early-stage breast cancer patients’ treatment using accelerated partial breast irradiation technique after breast-conserving surgery.
Materials and methods. The study enrolled 100 patients with histologically proven breast cancer pT1–2N0–micM0 who were treated in N.N. Blokhin National Medical Research Center of Oncology in 2008–2017. Median age – 65 years, median of follow-up – 36 months. All patients underwent breast-conserving surgical treatment (radical resection), radiation therapy and hormonal therapy if needed. Radiation therapy was performed in accelerated partial breast irradiation technique. All patients corresponded strict selection bias. For proper visualization and accurate delineation of tumor bed 94 % underwent clipping with radiopaque metal clips. All patients were treated with 3D-conformal radiation therapy in 2.5 Gy per fraction twice a day, overall dose 40 Gy (in 16 fractions).
Results. Median follow-up was 36 months. No locoregional recurrences or distant metastases were observed. Excellent and good cosmetic results were observed in 96 % patients.
Conclusions. Accelerated partial breast irradiation in very selected patients after breast-conserving surgery gives excellent clinical results, quite similar with those after whole breast irradiation.About the authors
O. P. Trofimova
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia ; Russian Medical Academy of Continuous Professional Education at the Ministry of Health of Russia
Author for correspondence.
Email: dr.Trofimova@mail.ru
23 Kashirskoe Shosse, Moscow 115478; 2/1 Barrikadnaya St., Moscow 123993
Russian FederationN. V. Volkova
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
23 Kashirskoe Shosse, Moscow 115478
Russian FederationA. V. Nazarenko
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
23 Kashirskoe Shosse, Moscow 115478
Russian FederationI. V. Kolyadina
Russian Medical Academy of Continuous Professional Education at the Ministry of Health of Russia
2/1 Barrikadnaya St., Moscow 123993
Russian FederationV. A. Haylenko
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
23 Kashirskoe Shosse, Moscow 115478
Russian FederationS. I. Tkachev
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
23 Kashirskoe Shosse, Moscow 115478
Russian FederationJ. I. Pryamikova
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
23 Kashirskoe Shosse, Moscow 115478
Russian FederationE. V. Timoshkina
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
23 Kashirskoe Shosse, Moscow 115478
Russian FederationO. S. Zaychenko
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
23 Kashirskoe Shosse, Moscow 115478
Russian FederationV. A. Boldyreva
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
23 Kashirskoe Shosse, Moscow 115478
Russian FederationI. K. Vorotnikov
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
23 Kashirskoe Shosse, Moscow 115478
Russian FederationS. B. Alieva
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
23 Kashirskoe Shosse, Moscow 115478
Russian FederationT. N. Borisova
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
23 Kashirskoe Shosse, Moscow 115478
Russian FederationV. V. Glebovskaya
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
23 Kashirskoe Shosse, Moscow 115478
Russian FederationS. M. Ivanov
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
23 Kashirskoe Shosse, Moscow 115478
Russian FederationReferences
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