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Опухоли женской репродуктивной системы

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ПРАКТИЧЕСКИЕ АСПЕКТЫ КЛИНИЧЕСКОГО ПРИМЕНЕНИЯ НОВОГО КЛАССА ПРЕПАРАТОВ – ИНГИБИТОРОВ ЦИКЛИНЗАВИСИМЫХ КИНАЗ: ЭФФЕКТИВНОСТЬ И ПЕРЕНОСИМОСТЬ ЛЕЧЕНИЯ

https://doi.org/10.17650/1994-4098-2018-14-1-52-60

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Аннотация

Метастатический рак молочной железы остается неизлечимым заболеванием, однако в последние годы в этой области были достигнуты весьма существенные успехи, позволяющие говорить о возможности его перевода в хроническую форму, характеризующуюся длительным торпидным течением. Особенно высока вероятность достижения относительно благоприятного клинического исхода при гормонозависимом HER2отрицательном подтипе опухоли. Такой результат стал возможен благодаря разработке и внедрению в клиническую практику высокоэффективной комбинированной лечебной стратегии, связанной с появлением нового класса лекарств – ингибиторов циклинзависимых киназ (CDK) 4 и 6. В статье представлен обзор результатов рандомизированных клинических исследований представителей этого класса препаратов с данными по их эффективности и безопасности. Показано, что нейтропения является класс-специфическим нежелательным явлением и характерна для всех 3 препаратов (палбоциклиба, рибоциклиба и абемациклиба); терапия рибоциклибом, кроме того, ассоциирована с гепатои кардиотоксичностью (удлинением интервала QTc); для абемациклиба, помимо нейтропении, характерны диарея и тромбоэмболии.

Об авторе

Е. В. Артамонова
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России
Россия

Артамонова Елена Владимировна

115478 Москва, Каширское шоссе, 23



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Для цитирования:


Артамонова Е.В. ПРАКТИЧЕСКИЕ АСПЕКТЫ КЛИНИЧЕСКОГО ПРИМЕНЕНИЯ НОВОГО КЛАССА ПРЕПАРАТОВ – ИНГИБИТОРОВ ЦИКЛИНЗАВИСИМЫХ КИНАЗ: ЭФФЕКТИВНОСТЬ И ПЕРЕНОСИМОСТЬ ЛЕЧЕНИЯ. Опухоли женской репродуктивной системы. 2018;14(1):52-60. https://doi.org/10.17650/1994-4098-2018-14-1-52-60

For citation:


Artamonova E.V. PRACTICAL ASPECTS OF ADMINISTERING CYCLIN-DEPENDENT KINASES INHIBITORS: EFFICACY AND TOLERABILITY. Tumors of female reproductive system. 2018;14(1):52-60. (In Russ.) https://doi.org/10.17650/1994-4098-2018-14-1-52-60

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ISSN 1994-4098 (Print)
ISSN 1999-8627 (Online)