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OVARIAN CANCER WITH SOLITARY BRAIN METASTASIS. A CLINICAL CASE OF PROLONGED (OVER 7 YEARS) COMPLETE REMISSION AFTER COMBINED TREATMENT

https://doi.org/10.17650/1994-4098-2018-14-1-96-101

Abstract

The article presents a clinical case of long-term complete remission after combined treatment in patient with metastasis of ovarian cancer in the brain. Duration of remission after treatment was more than 7 years.

About the Authors

N. V. Sevyan
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia
Russian Federation
23 Kashirskoe Shosse, Moscow 115478, Build. 2, 8 Trubetskaya St., Moscow 119991


V. В. Каrakhan
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
23 Kashirskoe Shosse, Moscow 115478


D. R. Naskhletashvili
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
23 Kashirskoe Shosse, Moscow 115478


A. Kh. Bekyashev
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
23 Kashirskoe Shosse, Moscow 115478


S. B. Alieva
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
23 Kashirskoe Shosse, Moscow 115478


D. M. Bеlоv
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
23 Kashirskoe Shosse, Moscow 115478


E. V. Prоzоrеnко
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia
Russian Federation
Build. 2, 8 Trubetskaya St., Moscow 119991


A. A. Мitrоfаnоv
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
23 Kashirskoe Shosse, Moscow 115478


L. T. Mamedova
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
23 Kashirskoe Shosse, Moscow 115478


References

1. Cohen Z.R., Suki D., Weinberg J.S. et al. Brain metastases in patients with ovarian carcinoma: prognostic factors and outcome. J Neurooncol 2004;66(3):313–25. PMID: 15015663.

2. Cormio G., Maneo A., Parma G. et al. Central nervous system metastases in patients with ovarian carcinoma. A report of 23 cases and a literature review. Ann Oncol 1995;6(6):571–4. PMID: 8573536.

3. Koul A., Loman N., Malander S. еt al. Two BRCA1-positive epithelial ovarian tumors with metastases to the central nervous system: a case report. Gynecol Oncol 2001;80(3):399–402. PMID: 11263939. DOI: 10.1006/gyno.2000.6085.

4. Pectasides D., Pectasides M., Economopoulos T. Brain metastases from epithelian ovarian cancer: a review of literature. Oncologist 2006;11(3):252–60. PMID: 16549809. DOI: 10.1634/theoncologist.11-3-252.

5. Sood A., Kumar L., Sood R., Sandhu M.S. Epithelial ovarian carcinoma metastatic to the central nervous system: a report on two cases with review of literature. Gynecol Oncol 1996;62(1):113–8. PMID: 8690282. DOI: 10.1006/gyno.1996.0199.

6. Melichar B., Urminská H., Kohlová T. et al. Brain metastases of epithelial ovarian carcinoma responding to cisplatin and gemcitabine combination chemotherapy: a case report and review of the literature. Gynecol Oncol 2004;94(2):267–76. PMID: 15297161. DOI: 10.1016/j.ygyno.2004.05.026.

7. Anupol N., Ghamande S., Odunsi K. Evaluation of prognostic factors and treatment modalities in ovarian cancer patients with brain metastases. Gynecol Oncol 2002;85(3):487–92. PMID: 12051879.

8. Rodriguez G.C., Soper J.T., Berchuck A. et al. Improved palliation of cerebral metastases in epithelial ovarian cancer using a combined modality approach including radiation therapy, chemotherapy, and surgery. J Clin Oncol 1992;10(10):1553–60. PMID: 1383433. DOI: 10.1200/JCO.1992.10.10.1553.

9. Kim Y.Z., Kwon J.H., Lim S. A clinical analysis of brain metastasis in gynecologic cancer: a retrospective multiinstitute analysis. J Korean Med Sci 201530 (1):66– 73. PMID: 25552885. DOI: 10.3346/jkms.2015.30.1.66.

10. Lévy C., Allouache D., Lacroix J. et al. REBECA: a phase I study of bevacizumab and whole-brain radiation therapy for the treatment of brain metastasis from solid tumours. Ann Oncol 2014;25(12):2351–6. PMID: 25274615. DOI: 10.1093/annonc/mdu465.

11. Belov D.M. Principles of surgical treatment of cerebral cancer metastases: choosing the tactics depending on the macrostructure: Summary of thesis … of candidate of medical sciences. Moscow, 2011. 26 p. (In Russ.).

12. Karakhan V.B. Primary and metastatic tumors of the central nervous system. Problemy klinicheskoy meditsiny = Problems of Clinical Medicine 2009;1:10–21. (In Russ.).

13. Naskhletashvili D.R., Gorbunova V.A., Bekyashev A.Kh. et al. Antitumor pharmacotherapy in the algorithm of complex treatment for metastatic brain tumors. Evraziyskiy onkologicheskiy zhurnal = Eurasian Journal of Oncology 2016;4(2):551. (In Russ.).

14. Mitrofanov A.A. Surgical and complex treatment of cerebral metastases of colorectal cancer. Summary of thesis … of candidate of medical sciences. Moscow, 2015. 26 p. (In Russ.).

15. Moskvina E.A. Capecitabine in combined treatment of metastatic brain lesions in patients with breast cancer. Summary of thesis … of candidate of medical sciences. Moscow, 2015. 26 p. (In Russ.).

16. Prozorenko E.V. Surgical treatment of cerebral metastases of malignant tumors with hemorrhage. Summary of thesis … of candidate of medical sciences. Moscow, 2015. 26 p. (In Russ.).

17. Sevyan N.V. Cerebral metastases of solid malignant tumors that rarely metastaze into the brain. Summary of thesis … of candidate of medical sciences. Moscow, 2013. 26 p.(In Russ.).

18. Mamedova L.T., Gritsay A.N., Shubina I. Zh. et al. Assessing the impact of neoadjuvant chemotherapy on the viability of tumor cells in ovarian cancer. Evraziyskiy onkologicheskiy zhurnal = Eurasian Journal of Oncology 2016;2:536. (In Russ.). DOI: 10.17650/1994‑4098‑2018‑14‑1‑96-101


Review

For citations:


Sevyan N.V., Каrakhan V.В., Naskhletashvili D.R., Bekyashev A.Kh., Alieva S.B., Bеlоv D.M., Prоzоrеnко E.V., Мitrоfаnоv A.A., Mamedova L.T. OVARIAN CANCER WITH SOLITARY BRAIN METASTASIS. A CLINICAL CASE OF PROLONGED (OVER 7 YEARS) COMPLETE REMISSION AFTER COMBINED TREATMENT. Tumors of female reproductive system. 2018;14(1):96-101. (In Russ.) https://doi.org/10.17650/1994-4098-2018-14-1-96-101

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ISSN 1994-4098 (Print)
ISSN 1999-8627 (Online)