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Effect of immunoadjuvants on the disease course in patients with operable breast cancer
- Authors: Vasilyeva M.M.1, Moshurov I.P.1, Grivtsova L.Y.2, Tupitsyn N.N.2, Kozlov N.A.3, Vasilyev M.B.1
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Affiliations:
- Voronezh Regional Clinical Oncology Dispensary
- N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
- N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russi
- Issue: Vol 14, No 4 (2018)
- Pages: 20-23
- Section: MAMMOLOGY. ORIGINAL REPORTS
- Published: 21.12.2018
- URL: https://ojrs.abvpress.ru/ojrs/article/view/615
- DOI: https://doi.org/10.17650/1994-4098-2018-14-4-20-23
- ID: 615
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Abstract
Background. A new strategy of breast cancer management is required for effective disease prevention and control. Immunotherapy is one of promising options.
Objective: to evaluate the effect of immunoadjuvant polyoxidonium on pathmorphological changes in breast tumors.
Materials and methods. The study was performed in 75 patients with breast cancer: 50 patients received polyoxidonium in a neoadjuvant regimen (main group), 25 patients did not receive polyoxidonium (control group). Polyoxidonium at a dose of 12 mg was administered intramuscularly 1 time per day on the days 1, 2, 3, 5 and 7 before surgery; on the day 8, radical mastectomy was performed in patients of both groups, followed by histological examination and determination of the grade of therapeutic pathomorphosis of the tumor.
Results. The proportion of cases with grade I therapeutic pathomorphosis was 58 %, grade II therapeutic pathomorphosis – 6 %. Pathomorphosis in metastatic lymph nodes was observed in 22.7 % of cases.
Conclusion. The anti-tumor effect of polyoxidonium was confirmed on the basis of the induction of pathomorphosis of the tumor tissue of breast cancer.
Keywords
About the authors
M. M. Vasilyeva
Voronezh Regional Clinical Oncology Dispensary
Author for correspondence.
Email: doctorvrachh@gmail.com
4 Vaytsekhovskogo St., Voronezh 394036
Russian FederationI. P. Moshurov
Voronezh Regional Clinical Oncology Dispensary
4 Vaytsekhovskogo St., Voronezh 394036
Russian FederationL. Yu. Grivtsova
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
ORCID iD: 0000-0001-9103-9688
24 Kashirskoe Shosse, Moscow 115478
Russian FederationN. N. Tupitsyn
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
ORCID iD: 0000-0003-3966-128X
24 Kashirskoe Shosse, Moscow 115478
Russian FederationN. A. Kozlov
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russi
24 Kashirskoe Shosse, Moscow 115478
Russian FederationM. B. Vasilyev
Voronezh Regional Clinical Oncology Dispensary
4 Vaytsekhovskogo St., Voronezh 394036
Russian FederationReferences
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